Sentences with phrase «human somatic»

Since the discovery that telomerase is repressed in most normal human somatic cells but strongly expressed in most human tumors, telomerase has become a target for therapeutic agents to combat human cancer.

However, this is inefficient and has a low throughput method so I aim to use our growing knowledge of epigenetics to devise strategies for «reprogramming» human somatic cells towards a stem cell like phenotype.

Most human somatic cells can undergo only a limited number of population doublings in vitro.

The goal of our laboratory is to generate pluripotent stem cells from human somatic cells.

The strict limit in proliferative potential of normal human somatic cells - a process known as replicative senescence - is highly relevant to the immune system, because clonal expansion is fundamental to adaptive immunity.

Reprogramming human somatic cells to pluripotency represents a valuable resource for the development of in vitro based models for human disease and holds tremendous potential for deriving patient - specific pluripotent stem cells.

Rago C, Vogelstein B, Bunz F. Genetic knockouts and knockins in human somatic cells.

In the following year, the direct reprogramming of human somatic cells was accomplished [2], [3].

The reprogramming of human somatic cells into induced pluripotent stem cells (iPSCs) offers tremendous potential for cell therapy, basic research, disease modeling, and drug development.

WIKIMEDIA, CSIROAfter human somatic cells are reprogrammed into induced pluripotent stem cells (iPSCs), the resulting cells retain both genetic and epigenetic indicators of the age of the person who donated the somatic - cell progenitors, scientists have found.

Kohli, Manu, et al. «Facile methods for generating human somatic cell gene knockouts using recombinant adeno ‐ associated viruses.»

It can reprogram human somatic (nonreproductive) cells, rewinding them back to an embryoniclike state.

The telomerase deficiency of human somatic cells reduces the risk of cancer development, as telomerase fuels uncontrolled cancer cell growth.

More recently, researchers have induced stem cells from diseased human somatic cells, which may serve as new model systems for various illnesses.

Human somatic cells have 46 chromosomes, whereas sperm and eggs have 23.

Not exact matches

It is impossible here to develop this theme more fully, nor is the lecturer competent to make the attempt; but we know that quite revolutionary changes in our traditional notions about human behavior have already taken place and even more revolutionary changes are likely to take place when the discoveries of depth - psychology and psycho - somatics have been given their proper recognition.

Even talk about a possible survival can not deny that patent fact, once we have understood the total organic, psycho - somatic, nature of our human existence.

The survey, described today in a Policy Forum published by Science, randomly presented people with different vignettes that described genome editing being used in germline or somatic cells to either treat disease or enhance a human with, say, a gene linked to higher IQ or eye color.

Meanwhile, recent human studies indicate that aging is associated with an increase in somatic mutations in the hematopoietic system, which gives rise to blood cells; these mutations provide a competitive growth advantage to the mutant hematopoietic cells, allowing for their clonal expansion — a process that has been shown to be associated with a greater incidence of atherosclerosis, though specifically how remains unclear.

«Investigators of aging in humans have been interested in studying somatic aging, and they've been interested in looking at the effects of age on fertility, but, in general, there haven't been any people trying to tie those two lines of investigation together,» saysTerry Hassold, a reproductive biologist at Washington State University in Pullman who was not involved in the study.

In May 2013, Mitalipov was the first scientist in the world to demonstrate the successful use of somatic cell nuclear transfer, or SCNT, to produce human embryonic stem cells from an individual's skin cell.

«Another future goal, however, is to use CRISPR - Cas9 for somatic gene therapy in humans with severe diseases,» Klaus Rajewsky pointed out.

These cloning experiments (known as somatic cell nuclear transfer), in addition to being unambiguously nonpresidential, require a rare and precious starting material: healthy human egg cells.

More than one - third of all human cancers are associated with somatic, or post-conception, mutations in Ras proteins, according to the NIH.

The law banned human cloning, although after a review in 2005 the law was amended the next year to allow therapeutic cloning, or somatic cell nuclear transfer.

L1 - associated genomic regions are deleted in somatic cells of the healthy human brain.

He reported in May 2013 using the Dolly technique, known more formally as somatic cell nuclear transfer, to derive stem cells from cloned human embryos, including from a baby with an inherited disorder.

The group, led by Hwang Woo Suk at Seoul National University, cloned human embryos using somatic cell nuclear transfer, a process that biologists have used to clone live animals.

In humans, somatic cells — the generic cells that grow into muscle, bone, and organs — start off unisex.

What somatic - cell nuclear transfer technology produces are cloned human embryos.

Whereas ejaculation is a somatic phenomenon, orgasm (as Shakespeare implies) is a phenomenon of the spirit, and even in human males a strict correlation between mind and matter hasn't been established.

The technique used by Wilmut and his co-workers — a technology called somatic - cell nuclear transfer — will probably be the way in which the first human clone will be created.

Opponents said that the measure should have banned somatic cell nuclear transfer; it criminalized only the «implantation» of an embryo into a woman to create a human clone.

But the favored reprogramming technique, somatic cell nuclear transfer (SCNT), otherwise known as research cloning, is fraught with ethical pitfalls as well as technical difficulties because it entails creating a human embryo by inserting an adult cell nucleus into an ooctye.

In these experiments, Berger and colleagues show that somatic PREX2 mutations identified through whole - genome sequencing of human melanoma can contribute to enhanced lethality of tumor xenografts in nude mice (Figure 3B, S6B, and S6C; Berger et al., 2012).

To sum up, we have seen that somatic cells of various origins, including human, can be lineage reprogrammed into induced neurons.

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

Human pluripotent stem cells from two sources today, one physiological embryonic stem cells «ES» from the embryo, and the other experimental cells «iPS» induced pluripotency by reprogramming genetic somatic cells.

Human embryos have been manufactured via somatic cell nuclear transfer (SCNT)-- the same process as that which

Ezh2 mediated H3K27me3 activity facilitates somatic transition during human pluripotent reprogramming.

An Open Label, Phase II Study of Neratinib in Patients with Solid Tumors with Somatic Human Epidermal Growth Factor Receptor (EGFR, HER2, HER3) Mutations or EGFR Gene Amplification

Our definition is similar to the European Medicines Agency (EMA) definition of Advanced Therapy Medicinal Product (ATMP): «Medicinal product for human use that is a gene therapy medicinal product, a somatic cell therapy medicinal product or tissue engineered product» (EMA ATMP Reg.

The Cancer, Ageing and Somatic Mutation Programme encompasses three Projects that respectively cover the genomics of human cancers; functional analysis of the cancer genome using a range of in vitro and in vivo model systems; and the characterisation of somatic mutations in development and adult homeostasis in health and dSomatic Mutation Programme encompasses three Projects that respectively cover the genomics of human cancers; functional analysis of the cancer genome using a range of in vitro and in vivo model systems; and the characterisation of somatic mutations in development and adult homeostasis in health and dsomatic mutations in development and adult homeostasis in health and disease.

COSMIC, the «Catalogue Of Somatic Mutations In Cancer» is an expert - curated database encompassing the wide variety of somatic mutation mechanisms causing human Somatic Mutations In Cancer» is an expert - curated database encompassing the wide variety of somatic mutation mechanisms causing human somatic mutation mechanisms causing human cancer.

Comparisons of genetically matched human pluripotent stem cells reveals that somatic cell nuclear transfer is the ideal means of generating cells for replacement therapy

Disease - specific human pluripotent stem cells, from embryonic origin or derived from reprogramming somatic cells, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells.

seek to identify the mutational processes underlying mutational signatures found in cancers, characterise the mutational processes operating in normal cells, use phylogenetic analyses of somatic mutations in humans to explore cellular lineages during embryonic development

Pluripotent stem cellderived somatic stem cells as tool to study the role of microRNAs in early human neural development

He was also a Fulbright Scholar, and was part of the team that cloned the world's first human embryo, as well as the first to successfully generate stem cells from adults using somatic - cell nuclear transfer (therapeutic cloning).