Sentences with phrase «human stem cell cultures»

While scientists have previously had success in 3D printing a range of human stem cell cultures developed from bone marrow or skin cells, a team from Scotland's Heriot - Watt University claims to be the first to print the more delicate, yet more flexible, human embryonic stem cells (hESCs).

Not exact matches

In both cases individual members may exercise some dominance over others, in particular by altering the patterns guiding further growth and development, but the social coordination stems from basic patterns embodied in the genetic makeup of the plant cells and in the laws and traditions of human culture.

When Gupta's team added salinomycin to cultured human breast - cancer cells, it was about 100 times as effective at killing the cancer stem cells as popular anti-cancer drug, paclitaxel.

Using human fetal «mini-brains» grown in 3 - D cultures, scientists determined that a specific protein produced by the Zika virus changes the properties of neural stem cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.

Confocal microscopy of human neural stem cell culture infected with Zika virus (red).

The team used human embryonic stem cells — which can transform into any cell of the body — and cultured them in a mixture of chemicals to grow human brain cells.

«We also think this method could be applied towards the development of culture conditions during differentiation of human stem cells.

2 - D cell - culture and mouse experiments also provided key evidence of the virus's modus operandi; although the rodent brain doesn't harbor the full contingent of human neural stem cells, it has blood vessels and immune - system components that organoids lack.

Finally, they demonstrated that zebrafish OPCs differentiate into mature oligodendrocytes when cultured together with human motor neurons, differentiated from induced pluripotent stem cells.

The work was led by Dan S. Kaufman, a hematologist, and James A. Thomson, the first scientist to grow human embryonic stem cells in culture.

Prior research with cultured tissue had shown that a mix of chemicals could change bone marrow stem cells from mice to those resembling brain cells, but when a team led by neurologist Lorraine Iacovitti of Thomas Jefferson University in Philadelphia tried the same brew on human cells, the number altered was modest.

To replicate these cell culture results, Rani used human stem cells to grow neurons into what is called a mini brain.

«Our group pioneered the development of cell culture technology for harvesting large numbers of stem cells from human bone marrow and human umbilical cord blood,» Dr. Yeh said, noting that stem cells from these two sources are abundant and can be guided into different types of cells using tissue engineering.

Scientists at the Institute of Reconstructive Neurobiology at the University of Bonn applied a recent development in stem cell research to tackle this limitation: they grew three - dimensional organoids in the cell culture dish, the structure of which is incredibly similar to that of the human brain.

By culturing human stem cells in this manner and treating them with specific signaling molecules, the investigators were able to guide cells through key processes involved in the development of the human inner ear.

Although a clause in the law that funds NIH prevents the agency from funding research that would harm or destroy an embryo, a lawyer at the Department of Health and Human Services ruled in 1999 that because stem cells — which can grow ad infinitum in culture — are not themselves embryos, the NIH could fund work with cells that were derived by privately funded researchers or researchers overseas.

«The resulting hydrogel composed of physically self - assembled CarHC polymers exhibited a rapid gel - sol transition on light exposure, which enabled the facile release / recovery of 3T3 fibroblasts and human mesenchymal stem cells (hMSCs) from 3D cultures while maintaining their viability.»

RIKEN researchers have taken up this challenge, and the work published in Cell Reports details how sequentially applying several signaling molecules to three - dimensional cultures of human embryotic stem cells prompts the cells to differentiate into functioning cerebellar neurons that self - organize to form the proper dorsal / ventral patterning and multi-layer structure found in the natural developing cerebellum.

Ralph Brinster, part of the team at the University of Pennsylvania in Philadelphia that first cultured sperm stem cells in the lab, has written that culturing stem cells from human sperm is not far off — humans and mice, like other mammals, he says, require similar growth factors.

Scientists at the University of Luxembourg have succeeded in turning human stem cells derived from skin samples into tiny, 3 - D, brain - like cultures that behave very similarly to cells in the human midbrain.

Expanding from their previous studies with mice, the researchers first established that under specific conditions, culturing human embryonic stem cells with fibroblast growth factor 2 (FGF2) leads to neural differentiation particular to the midbrain / hindbrain region — the location of the cerebellum — within three weeks, and the expression of markers for the cerebellar plate neuroepithelium — the part of the developing nervous system specific for the cerebellum — within five.

When BMP protein was added for three days in human pluripotent stem cell - derived gut tube cultures, it induced a posterior HOX code.

Surgeons report success in first human bone growth procedure using fat stem cells — with no culturing necessary

In work published on 24 November in the journal Nature biotechnology, Anselme Perrier's team at I - Stem identified a recurrent anomaly in the genome of human embryonic stem cells left in culture for too lStem identified a recurrent anomaly in the genome of human embryonic stem cells left in culture for too lstem cells left in culture for too long.

«The region selective - state of these stem cells is entirely novel for laboratory - cultured stem cells and offers important insight into how human stem cells might be differentiated into derivatives that give rise to a wide range of tissues and organs,» says Jun Wu, a postdoctoral researcher in Izpisua Belmonte's lab and first author of the new paper.

They then inserted the spatially oriented human stem cells (human rsPSCs) into specific regions of partially dissected mouse embryos and cultured them in a dish for 36 hours.

Morphological and immunocytochemical characteristics indicate the yield of early progenitors and represent a quality control for human mesenchymal stem cell culturing.

It facilitates self - renewal of both pluripotent human embryonic stem cells and induced pluripotent stem cells in a chemically defined, feeder - free and animal - protein free cell culture system.

Bartosz Balana (Ravens, TUD)-- «Influence of culture conditions on differentiation and bioelectrical properties of human mesenchymal stem cells» (2005)

Stem cell culturing of human ES and iPS cells on recombinant laminin matrices is easy and efficient.

Buy human recombinant laminins from BioLamina - culture stem cells, differentiate to neurons, RPE cells, cardiomyocytes and other cells on their specific laminin isoform.

Differences between in vitro viability and differentiation and in vivo bone - forming efficacy of human mesenchymal stem cells cultured on PCL - TCP scaffolds.

This enables robust stem cell culture methods that in practical solves all current technical challenges with culturing human ES and iPS cells.

Differential osteogenicity of multiple donor - derived human mesenchymal stem cells and osteoblasts in monolayer, scaffold - based 3D culture and in vivo.

All the hES and human induced pluripotent stem cell lines were confirmed to be genetically stable and pluripotent in in vivo and in vitro assays after extensive culturing on the new substrata.

The DEF - CS system is a robust culture system for efficient expansion of human induced pluripotent stem (iPS) cells in a feeder - free and defined environment.

Three - dimensional neuroepithelial culture from human embryonic stem cells and its use for quantitative conversion to retinal pigment epithelium.

Gage's team used human pluripotent stem cells to develop brain organoids, which were grown in culture for 40 to 50 days.

Small, transient populations of these totipotent cells are found in both mouse and human cultured stem cells.

Human recombinant laminin isoforms are developed for defined and xeno - free stem cell culturing and primary cell cultures.

StemFit Basic02 is a xeno - free, defined medium for human pluripotent stem cell (hiPSC) culture that offers an effective solution for regenerative medicine research.

Laminin - 521 human stem cell matrix makes pluripotent stem cell culture easy in a defined, xeno - free and biologically relevant cell culture system.

One Standardized Differentiation Procedure Robustly Generates Homogenous Hepatocyte Cultures Displaying Metabolic Diversity from a Large Panel of Human Pluripotent Stem Cells.

Researchers discover that the inhibition of a lysine methyltransferase allows for the long - culture and amplification of human muscle stem cells

We use 3D stem cell («organoid») cultures from mice and humans to examine occurrence, level and molecular causes of CIN in cancer (Video 2).

Since human embryonic stem cells grow in an adherent culture system, for cells being reprogrammed this «new culture system» is an adherent culture system (to try and mimic the conditions the embryonic stem cells want to be happy).

The study used three cell types: human motor neurons derived from induced pluripotent stem cells, rat cortical cultures, and human breast cancer cells.

PromoKine is a brand of PromoCell, a premier manufacturer of cell culture products which is especially recognized for its broad range of human primary cells, stem cells, and blood cells as well as optimized cell culture media.

The latest round of CIRM grants, totaling more than $ 50 million, will finance construction of shared research laboratories at 17 academic and non-profit institutions for the culture of human embryonic stem cells (hESCs), particularly those that fall outside federal guidelines.