On 1 May 2002, CNPR incorporated to become MerLion Pharmaceuticals, a home - grown Singapore drug discovery company that aims to develop new drugs for
human therapy from natural product leads.
Not exact matches
At the same time we must allow
therapy to make its contribution by disentangling the self
from unfortunate patterns of
human parenting that are being confused with the parenting of God.
Despite any clinical evidence for or against the
therapy, the APA denounces such
therapy because, «In the current social climate, claiming homosexuality is a mental disorder stems
from efforts to discredit the growing social acceptance of homosexuality as a normal variant of
human sexuality.
Applies the learnings
from existential
therapy to help readers understand the
human predicament and rediscover their selfhood.
The growth counselor can use the
human potentials and lifelong development perspectives as the hub of the wheel around which insights and methods
from the newer growth oriented psychotherapies — e.g., reality
therapy, transactional analysis, gestalt
therapy, action
therapies — can be integrated.
From this stream, I will ex-plore (in chapter II) the remarkable growth resources in psychosynthesis, which is also a
human potentials
therapy.
It's really encouraging to read your story
from every perspective: as a friend, student of counseling and creative
therapies, and a
human who has lows.
This paper offers a challenge to the BTSC
from two perspectives: (1) the questionable validity of SIDS mortality and risk statistics, and (2) the BTSC as
human experimentation rather than as confirmed preventive
therapy.
In advance of receiving an award
from the
Human Rights Campaign, Cuomo announced a series of measures intended to eliminate so - called conversion
therapy, a practice that claims the ability to reverse same - sex attraction in some people but that has been widely discredited by scientists and criticized by gay - rights groups.
Interactions between these two genomes, which affect everything
from health and physiology to fitness, have important consequences for
human health and medical interventions such as mitochondrial replacement
therapy in embryos.
The investigators caution the approach is years away
from use in
humans, but gene
therapy carries the promise of restoring hearing in people with several forms of both genetic and acquired deafness.
Currently, Deng's laboratory is conducting additional preclinical studies using the
human - derived stem cells
from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline
therapy and other candidate drugs.
The journal provides cutting - edge research including results
from animal models that are likely to apply to patients, studies in
human tissue that provide new information about
therapies or disease, and innovative reports of drug discovery and development.
The researchers hope that ultimately
human trials will prove the efficacy of the OH14 compound in sensitising tumour cells and cancer stem cells to existing drug - based
therapies thus disabling tumours
from seeding new growth after treatment.
Additionally, work in a mouse model revealed similar cells, indicating that the progenitors are conserved
from mouse to
human, and therefore, they must be «important cells with promising potential for cell
therapy in treating liver disease,» explained Dr. Gouon - Evans.
To that end, in collaboration with the University of Zurich and MD Anderson Cancer Center, the researchers tested melanoma tumor samples
from human patients undergoing treatment with the same targeted
therapies.
Last year the National Institutes of Health announced plans to put some 180 ex-Coulston chimps currently housed at the Alamogordo Primate Facility back in service, to rejoin the roughly 800 other chimps that serve as subjects for studies of
human diseases,
therapies and vaccines in the U.S., which is the only country apart
from Gabon to maintain chimps for this purpose.
The new epidermis, grown
from human pluripotent stem cells, offers a cost - effective alternative lab model for testing drugs and cosmetics, and could also help to develop new
therapies for rare and common skin disorders.
«If people are very frail, they typically don't respond well to anti-hypertensive
therapy and they are not benefiting
from having a low blood pressure,» said lead author Chenkai Wu, a graduate student in OSU's College of Public Health and
Human Sciences.
«Investigators create complex kidney structures
from human stem cells derived
from adults: New technique offers model for studying disease, progress toward cell
therapy.»
Such research is not currently eligible for NIH funding, and is still years
from producing
therapies that regulators would have to green light before they could be tested in
humans.
«ELITE provides proof of concept and first direct evidence
from human investigation that timing of hormone
therapy is imperative for success in the prevention of atherosclerosis progression, the primary underlying pathway that leads to heart disease and stroke,» Hodis added.
Stem cells obtained
from human embryos seem to offer the best chance of new
therapies, because unlike other stem cells they have the ability to morph into almost any type of tissue.
The phase II trial, which involves 28 kids
from 16 countries, is the first to evaluate a
therapy in
humans against this disease.
It uses a virus already approved by the Food & Drug Administration for other genetic
therapies in the eye; it delivers an ion channel gene similar to one normally found in
humans, unlike others that employ genes
from other species; and it can easily be reversed or adjusted by supplying new chemical photoswitches.
A new genetic
therapy not only helped blind mice regain enough light sensitivity to distinguish flashing
from non-flashing lights, but also restored light response to the retinas of dogs, setting the stage for future clinical trials of the
therapy in
humans.
Over the past two years, investigators
from the Perelman School of Medicine at the University of Pennsylvania have reported results
from a
human trial in GBM using chimeric antigen receptor (CAR) T cell
therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.
A few
therapies derived
from human medicine are available for dogs.
In a letter published in the cancer journal Annals of Oncology, researchers led by Professor Jean - Philippe Spano, head of the medical oncology department at Pitie - Salpetriere Hospital AP - HP in Paris, France, report that while treating an HIV - infected lung cancer patient with the cancer drug nivolumab, they observed a «drastic and persistent decrease» in the reservoirs of cells in the body where the
human immunodeficiency virus (HIV) is able to hide away
from attack by anti-retroviral
therapy.
«The primary mission of the USC Neurorestoration Center is to take advantage of resources
from our clinical programs to create unique opportunities to translate scientific discoveries, such as those of the Andersen Lab at Caltech, to
human patients, ultimately turning transformative discoveries into effective
therapies,» says center director Charles Y. Liu, professor of neurological surgery, neurology, and biomedical engineering at USC, who led the surgical implant procedure and the USC / Rancho Los Amigos team in the collaboration.
If the
therapy translates to
humans, it could be a boon for soldiers returning
from war, who sometimes wait weeks between leaving the battlefield and arriving home for treatment.
While the anatomy of the murine nose differs
from that of
humans, the researchers plan to study the
therapy further with the hope it will be broadly applicable.
For the animal experiments, Savio Woo of the Center for Gene
Therapy at Baylor College of Medicine in Houston and his colleagues first isolated liver cells
from transgenic mice that produce the
human protein a1 - antitrypsin in their livers,
from where it is secreted into the blood.
When I joined they made the move
from animal cloning to
human therapy, and we knew we would get hit, big - time.
FDA also approves so - called biologics, which include products made
from human tissues, blood, and cells, and gene
therapy techniques.
That's a long way
from it working in people, but because it seems a safe
therapy, it could move quickly into
human trials.
Thus far, the Newcastle team has worked with abnormally fertilized
human eggs that will not develop into viable embryos; the new money will allow them to use normal, leftover eggs
from IVF
therapy.
Dr. Hashino said these findings are «a real game changer, because up until now, potential drugs or
therapies have been tested on animal cells, which often behave differently
from human cells.»
Researchers at the Institute for Stem Cell
Therapy and Exploration of Monogenic Diseases (I - Stem — Inserm / AFM / UEVE), in collaboration with CNRS and Paris Descartes University, have recently developed a new approach to better control the differentiation of
human pluripotent stem cells, and thus produce different populations of motor neurons
from these cells in only 14 days.
Based on the observation that obese mice, rats, and
humans all had elevated serum concentrations of a protein called GDF15 compared to lean controls, Yumei Xiong and colleagues set out to develop
therapies derived
from the molecule.
«For a stem cell
therapy for Duchenne to move forward, we must have a better understanding of the cells we are generating
from human pluripotent stem cells compared to the muscle stem cells found naturally in the
human body and during the development process.»
The total radiation delivered, 0.5 gray (Gy), was high relative to environmental levels (
from sources such as naturally occurring radon in rock), but significantly lower than equivalent
human doses experienced in CAT - scans or cancer
therapy.
Past clinical trials of stem cell
therapies for chronic stroke patients used cells derived
from tumors in
humans and brain tissue
from fetal pigs.
Human epidermis has been produced in vitro for decades using adult epidermal stem cells
from donors to provide cell
therapy.
For the first time, through the use of
human embryonic stem cells (hES) sourced
from pre-implantation diagnosis, researchers
from Inserm's Institute for Stem Cell
Therapy and Exploration of Monogenic Diseases (I - Stem) have successfully identified the previously unknown mechanisms involved in Steinert» disease, also known as type 1 myotonic dystrophy.
A full realisation of the medical potential of stem cells for
human health will likely depend on a reinforcement of, and development of a whole continuum of studies ranging
from those in vivo using model organisms, to cell - based
therapies in the clinic.
In the current work we used adenoviral - type 5 (dE1 / E3)(Cytomegalovirus promoter) with
human ABCA10 transgene (Ad - h - ABCA10) purchased
from Vector Labs ® in order to investigate whether gene
therapy can be used as a pre-treatment to enhance the efficiency of inhaled cisplatin.
Researchers at UCLA treat the first patients in the second FDA - approved study evaluating a
therapy made
from human embryonic stem cells.
Specific Aim 2: Having utilized mutant mice to identify the key players in AMD pathology
from Specific Aim 1, we will develop and test molecules that target either the anaphylatoxins or the MAC, or both, in the context of practical
therapies that can be utilized in
humans.
How would this development (and whatever drug or
therapy they devise for
humans) move
from the lab and into trials, without it taking decades, like the author here proposes?