Sentences with phrase «human tissue models»

Dr. Falk is also PI of an NIH, pharma, and philanthropic funded translational research laboratory group at CHOP that investigates the causes and global metabolic consequences of mitochondrial disease, as well as targeted therapies, in C. elegans, zebrafish, mouse, and human tissue models of genetic - based respiratory chain dysfunction, and directs multiple clinical treatment trials in mitochondrial disease patients.

For the published request for applications, see the April 7, 2016 Guide announcement, Human Tissue Models for Infectious Diseases (U19).

As well as allowing the use of stem cells grown from established cell lines, the technology could enable the creation of improved human tissue models for drug testing and potentially even purpose - built replacement organs.

Not exact matches

Such models can recreate the complex layers of tissue in the human body to study a practically infinite number of grievous wounds from all angles, speeds, and styles of bullets (or even shrapnel from mines and improvised explosive devices).

Human tissue grown in the laboratory offers a critical model for understanding the disease process.

Three - dimensional models of living tissue will advance understanding of human breast development as well as the growth of breast cancer.

PDX models are created by implanting cancerous tissue from a human primary tumor directly into immunodeficient mouse or rat models, enabling acceleration of oncology research or drug discovery and development programs.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

The journal provides cutting - edge research including results from animal models that are likely to apply to patients, studies in human tissue that provide new information about therapies or disease, and innovative reports of drug discovery and development.

Using a mouse model of HSV - 1 as well as autopsied samples of human adult and fetal tissues, investigators from Dartmouth College's Geisel School of Medicine found that antibodies against HSV - 1 produced by adult women or female mice could travel to the nervous systems of their yet unborn babies, preventing the development and spread of infection during birth.

Dr. Wang plans to continue studying the effects of TNF and IL - 17 on melanocytes, and would like to expand the research to 3D skin models — fabricated samples of tissue in vitro that behave like human skin — that would give a better visual of how the melanin production process is being disrupted by these two cytokines during skin inflammation or wound healing.

In 2010, Radovitzky's group, working in concert with the Defense and Veterans Brain Injury Center, a part of the U.S. military health system, developed a highly sophisticated, image - based computational model of the human head that illustrates the ways in which pressurized air moves through its soft tissues.

To make a more accurate, responsive model of human injury, nearly two dozen automakers and research institutes have set out together to build a digital complement: an elaborate, 3 - D computer model depicting bone, tissue and internal organs from head to toe.

Mardinoglu says the team's network modeling approach, which relied on data from the Sweden - based Human Protein Atlas project and The Genotype - Tissue Expression (GTEx) project consortia, can be used in the identification of drug targets and eventually in the development of efficient strategies for treating a number of chronic liver diseases.

To test this idea, the researchers utilized two mouse models of human breast cancer metastasis and found dormant disseminated tumor cells residing upon the membrane microvasculature of lung, bone marrow and brain tissue.

One postdoc presents data on her efforts to develop an organoid model for small - cell lung cancer; another reports progress on culturing hormone - secreting organoids from human gut tissue.

From left: Image showing muscle, fat and intramuscular connective tissue; 3D human lower leg model constructed from 25 images, consisting of 73,659 nodes (pixel points).

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

But if homologous recombination could be worked out in human (embryonic) stem cells, then cardiomyocytes with mutations in ion channels could be derived, as well as a large number of other very useful disease models of other tissues.

Human tumor tissue or cell lines can be coengrafted into these mouse models, providing a powerful tool for studying the interactions between human immune cells and human canHuman tumor tissue or cell lines can be coengrafted into these mouse models, providing a powerful tool for studying the interactions between human immune cells and human canhuman immune cells and human canhuman cancers.

This research is all aimed at tissue repair strategies, but it also may provide new in vitro models for human disease.

The scientists are able to use tissue not only from laboratory mouse models, but also from human patients.

A UCSF - led team has developed a technique to build tiny models of human tissues, called organoids, more precisely than ever before using a process that turns human cells into a biological equivalent of LEGO bricks.

When transplanted to an animal model of corneal blindness, these tissues are shown to repair the front of the eye and restore vision, which scientists say could pave the way for human clinical trials of anterior eye transplantation to restore lost or damaged vision.

Historically, animal models — from fruit flies to mice — have been the go - to technique to study the biological consequences of aging, especially in tissues that can't be easily sampled from living humans, like the brain.

They also hope to use what they learn from simple models of different tissue types to ultimately build functional human tissues like lung and kidney and neural circuits using larger - scale techniques.

When RNAi therapies weren't delivered to the right tissues, dangerous side effects showed up in humans that weren't predicted through animal models.

So we tested this in mouse models and in human polycystic kidney tissues, and, in both cases, high levels of pIgR were expressed in kidney cysts.»

To make such a detailed model, researchers took specks of brain tissue and cut them into slices thousands of times thinner than a human hair.

Models using human tissues, reproducing key features of biochemistry and physiology, have enormous potential in brain research.

«Engineered cardiac tissue model developed to study human heart.»

That's because they may have finally developed a tissue model for the human heart that can bridge the gap between animal models and human patients.

As the object of study was the human body and its biological tissue, a 3D model of a human body compatible with the chosen simulation technique was developed.

Previous research in rodent disease models has shown that transplanted oligodendrocyte precursor cells derived from embryonic stem cells and from human fetal brain tissue can successfully create myelin sheaths around nerve cells, sometimes leading to dramatic improvements in symptoms.

After confirming in mouse models that cells from HER2 - positive breast cancers became resistant to anti-HER2 treatment when implanted into the brain but not into other tissues, the investigators found that HER3 is overexpressed in brain metastases of HER2 - positive breast cancers from both mice and human patients.

Using both the test tube and human data, Kashuba and her team created a mathematical model that predicts the drug - to - DNA ratios in vaginal, cervical and rectal tissues and calculates the amount of drug needed to prevent HIV from infecting human tissues.

The researchers studied tumour tissue from patients, cultivated human tumour cells and tumours in mouse models for neuroblastoma.

For example, a non-Newtonian model would be needed for 3 - D printing polymers and biomaterials, such as human tissue and organs.

She added that, «attempts to generate the cerebellum from human iPS cells have already met with some success, and these patient - derived cerebellar neurons and tissues will be useful for modeling cerebellar diseases such as spinocerebellar ataxia.»

David Kaplan, Ph.D., professor and Director of the NIH P41 Resource Center on Tissue Engineering, Alessandra Balduini, M.D., and their collaborators have focused on forming bone marrow models with these components and other growth factors to imitate and support the formation of functional human platelets.

Researchers funded by the National Institute of Biomedical Imaging and Bioengineering at Tufts University and their collaborators have successfully developed a 3 - dimensional (3D) tissue - engineered model of bone marrow that can produce functional human platelets outside the body (ex vivo).

Anand hopes his brain model could be incorporated into the Microphysiological Systems program, a platform the Defense Advanced Research Projects Agency is developing by using engineered human tissue to mimic human physiological systems.

Dr. Bruce Conklin and colleagues from Gladstone and UC Berkeley grew beating heart tissue from stem cells, creating a model of early human heart development.

iPS cells enable to enlarge applications for modeling numerous human pathologies, reproducing the dysfunction processes of damaged tissue, and developing targeted medicine.

«Next, we'd like to show that these different human progenitor cells can regenerate their respective tissues and perhaps even ameliorate disease in animal models,» said Loh.

The next step, he says, will be to use his team's three - dimensional «Alzheimer's in a dish» model to see whether microbes can induce amyloid - beta plaques to form in human brain tissue, and then whether those plaques lead to tau tangles and inflammation.

By tweaking an animal's DNA or using other means to inflict changes in their cells and tissues, some organisms can closely model human diseases.

So using as few of them as possible to create models of human tissue and organs saves money.

Results: Pacific Northwest National Laboratory researchers and collaborators have shown for the first time that human noroviruses can infect and replicate in a three - dimensional model of human small intestinal tissue.

We are using mouse models in conjunction with human tissue analysis to understand how this fibrosis arises and how it can be altered to allow access of chemotherapeutic agents to the tumor.