Sentences with phrase «human tissue types»

An international consortium of researchers in the Genotype - Tissue Expression (GTEx) Consortium published findings about how genetic variation effects gene regulation in 44 human tissue types.

To demonstrate the precision of the technique and its ability to generalize to many different human tissue types, the research team created several proof - of - principle organoid arrays mimicking human tissues such as branching vasculature and mammary glands.

Not exact matches

The human body contains two types of fat tissue, white fat and brown fat.

This type of dermal filler is biocompatible, which means that it will have very little reaction to human tissue.

The Human Genome Project, which sequenced the 3 billion pairs of nucleotide bases in human DNA, was a piece of cake in comparison: Epigenetic markers and patterns are different in every tissue type in the human body and also change over Human Genome Project, which sequenced the 3 billion pairs of nucleotide bases in human DNA, was a piece of cake in comparison: Epigenetic markers and patterns are different in every tissue type in the human body and also change over human DNA, was a piece of cake in comparison: Epigenetic markers and patterns are different in every tissue type in the human body and also change over human body and also change over time.

Working with human breast tissue, the new study's authors attempted to induce EMT in normal cells; they figured they would just get fibroblasts, a type of connective tissue that is important in wound healing.

The researchers have compared various processes involved in gene expression, such as gene transcription and chromatin modification, and have repeated this in different tissues and cell types from both humans and mice.

The newly discovered human cells, named «cord - blood - derived embryonic - like stem cells» or CBEs, are not quite as primitive as embryonic stem cells, which can give rise to any tissue type of the body.

Wells's team first turned human skin cells into pluripotent stem cells, which can grow into any type of tissue.

In 2008 the National Institutes of Health launched the $ 190 - million Roadmap Epigenomics Project with the goal of cataloguing the epigenetic marks in the major human cell types and tissues.

The research team then examined human pancreatic tissue from type 1 diabetics, finding strong evidence that the same process induced by caerulein also occurred in the pancreases of those individuals.

Iwasaki and colleagues next added type I interferon to samples of human placental tissue in dishes.

The latter type of research, in which human cells or tissue are integrated into animals, was given the green light in the United Kingdom in October 2008, when the British House of Commons approved a bill that expanded the country's rules governing work with human embryos.

They also applied it to human brain tissue collected by the Genotype - Tissue Expression (GTEx) Project, finding that they could a) identify expression signatures unique to neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cell subtissue collected by the Genotype - Tissue Expression (GTEx) Project, finding that they could a) identify expression signatures unique to neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cell subTissue Expression (GTEx) Project, finding that they could a) identify expression signatures unique to neurons, glial cells, and other cell types in the brain (including rare types), and b) differentiate between closely related cell subtypes.

Greg Fahy of the American Red Cross in Bethesda, Maryland, said last week that he and his colleagues hope to have developed a method for preserving rabbit kidneys — which are very similar in tissue type and structure to human ones — by Christmas.

To streamline this process, Uhlén's team has created standardized arrays containing microscopic samples from 48 kinds of normal human tissue and 20 types of tumors.

The researchers next will turn to analyzing the presence of myoferlin in samples from numerous human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in tumors to clinical outcomes for the patients who provided the samples.

The results suggest that drugs capable of targeting similar molecular pathways in human fat cells could one day become major tools for fighting the growing worldwide epidemics of obesity and type 2 diabetes, according to senior investigator Shingo Kajimura, PhD, an assistant professor of cell and tissue biology in UCSF's School of Dentistry.

In humans, Salmonella Dublin has higher hospitalization and fatality rates than other Salmonella types; it causes systemic infection of body tissues, similar to typhoid.

«We can apply this method to any type of clinical sample and all types of human tissues, including normal and cancerous tissues,» said co-lead author Yongxin Zhao, PhD, of MIT's Media Lab.

Scientists have demonstrated a method for generating several key types of eye tissue from human stem cells in a way that mirrors whole eye development.

There are two types of fat in humans: white adipose tissue, which makes up nearly all the fat in adults, and brown adipose tissue, which is found in babies but disappears as they age.

They also hope to use what they learn from simple models of different tissue types to ultimately build functional human tissues like lung and kidney and neural circuits using larger - scale techniques.

Stem cells obtained from human embryos seem to offer the best chance of new therapies, because unlike other stem cells they have the ability to morph into almost any type of tissue.

«It was hard to find a single microRNA in the human genome that wasn't differentially turned on or off across different tumor types in different tissues,» Golub says.

DNA methylation age of human tissues and cell types.

«Our group pioneered the development of cell culture technology for harvesting large numbers of stem cells from human bone marrow and human umbilical cord blood,» Dr. Yeh said, noting that stem cells from these two sources are abundant and can be guided into different types of cells using tissue engineering.

In a study in Proceedings of the National Academy of Sciences, Dr. Snyder and his colleagues compared gene expression in 15 different tissue types in mice and humans.

So, at the dawn of our universe — and I have to emphasize our universe, because there could be others — so, dawn of our universe, physicists think there was one type of force, one type of matter and that as the cosmos expanded, as space expanded, it cooled and things started to condense out like snow flakes, and over time that single force broke, it differentiated; and something similar happens in the human body as we develop from a single cell; we differentiate, different tissues form in our bodies, different layers of tissues.

«Our work outlines the genetic similarities of the tissue and cells in different types of tumors and shows the strong relationships mice can have to other human cancers too.»

In the Nature papers, the researchers compared gene transcription, chromatin modification and other processes that control gene activity in a wide range of mouse and human tissues and cell types.

«This process contributes to about 200 different cell types in humans and other mammals, but analyzing them will be difficult, because they will need to be studied in a tissue.»

The research highlights the importance of investigating different cell types in normal human tissues to understand the cellular origin of cancer and the factors that may contribute to its development.

The ability of scientists to convert human skin cells into other cell types, such as neurons, has the potential to enhance understanding of disease and lead to finding new ways to heal damaged tissues and organs, a field called regenerative medicine.

Phages, shown here surrounding and attacking a bacterial cell, are part of a newly discovered type of immunity that protects mucus - covered human tissue from bacterial infection.

Furthermore, they integrated single - cell datasets of pancreatic tissue from humans and mice, thereby identifying 10 cell types that were shared across species and defining the evolutionary changes occurring in each group.

The team hopes to apply GLIM technology to human fertility research and treatment, as well as a range of different types of tissue research.

Two types of fat tissue are present in humans and other mammals: white adipose tissue (WAT) or white fat, which stores fat; and brown adipose tissue (BAT) or brown fat, which burns fat to produce heat.

One of my favorite papers from this year was the landmark publication of the NIH Epigenomics Roadmap Consortium, which profiled 111 primary human tissues and cell types for histone modification patterns, DNA accessibility, DNA methylation, and gene expression.

He added: «Truly naive human ES cell lines would not only help answer fundamental questions about how we are made, and be useful for drug screening and tissue therapy, but they would also provide a benchmark against which other types of stem cells could be measured in terms of their effectiveness in stem cell therapy and regenerative medicine.»

Humans obviously regenerate some cell types very well, such as skin, muscle and liver cells, but almost not at all in cells of the nervous system or with any complex tissue systems.

Typically, this involves creating a «scaffold» of natural or synthetic materials, seeding it with human stem cells that can differentiate themselves into particular tissue types, and providing the cells with nutrients and a physical environment that encourages them to take on the three - dimensional structures and functions of a particular body part.

Scientists at the University of Cambridge have for the first time shown that it is possible to derive from a human embryo so - called «naïve» pluripotent stem cells — one of the most flexible types of stem cell, which can develop into all human tissue other than the placenta.

Unlike other cell types, stem cells are unspecialized cells uniquely capable of making copies of themselves (self - renewing), differentiating into specialized cell types, and helping to maintain some tissues in the human body.

In humans just one type of cross-linking compound called glucosepane accounts for almost all such cross-links in the most studied tissues.

Unlike embryonic stem cells, which are developmental blank slates that can generate virtually all types of cells found in adult humans, adult stem cells are thought to possess limited potential to transform into cells found in their tissues of origin.

Yet this study brings us tantalisingly close to using skin cells to grow many different types of human tissues.

He later combined it with studies on chromatin, tissue specific gene expression and mouse models for human diseases including Type II diabetes, polycystic kidney disease as well as cancer.

Researchers had developed the technologies needed to create organoids years before — how to grow cells in culture, how to isolate stem cells from human tissue, and how to coax the stem cells, undifferentiated and immature, to become specific types of cells at later stages of development.

The resulting organoids sported different tissue types and were «similar» to the kidney of a human embryo, the researchers reported.