Two components, counterparts of
human transcription factor IIF (TFIIF) and TFIIH, could be exchanged individually between systems without effect on the start site.
In the work published in Cell, the scientists at Karolinska Institutet describe DNA sequences that bind to over 400 such proteins, representing approximately half of
all human transcription factors.
The researchers analyzed hundreds of
human transcription factors, which are proteins that read the genetic information coded in DNA's sequence of four nucleotide bases — adenine (A), cytosine (C), guanine (G) and thymine (T)-- and pass that on to RNA molecules.
CDI HuProt microarrays are currently being employed in an NIH grant to produce antibodies with absolute specificity to all of the human transcription factors
CDI HuProt microarrays are currently being employed in an NIH grant to produce antibodies with absolute specificity to
all human transcription factors.
Together, EBNA2 and
the human transcription factors change the expression of neighboring viral genes.
TCF class is a classification of
human transcription factors (TFs) and their mouse orthologs based on the characteristics of their DNA - binding domains.
Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lamarie P, Ukkonen E, Kivioja T, Taipale J. DNA - Binding Specificities of
Human Transcription Factors.
Wingender E, Schoeps T, Dönitz J. TFClass: an expandable hierarchical classification of
human transcription factors.