Sentences with phrase «human tumor antigens»
Lloyd Old, Thierry Boon, and colleagues develop the TNF release assay for mouse systems in which release of TNF by T cells could be used to assess specific T cell recognition, facilitating the cloning of human tumor antigens.
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Dr. Gnjatic's research focuses on human antigen - specific immune responses to tumor antigens, in an attempt to define new targets for the development of cancer immunotherapies, assess the efficacy of these immunotherapies, and learn why they may fail.
Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.
Pramod Srivastava and Lloyd J. Old identify the human homologue of the mouse tumor rejection antigen gp96.
Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor.
Pierre Coulie and Thierry Boon, [i] and Thomas Wölfel [ii] show that human T lymphocytes recognize antigens caused by driver278 or passenger279 tumor - specific mutations.
Antonio Lanzavecchia finds that efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte / macrophage colony - stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.
mesothelin - specific chimeric antigen receptor (CAR) were capable of ablating large human mesothelioma tumors when infused into mice.
Recently she characterized anti-tumor effects of a unique human CD4 + helper T - cell subset that directly recognizes the cytoplasmic tumor antigen, NY - ESO - 1, presented by MHC class II on cancer cells.
Revealed that the loss of the human leukocyte antigen (HLA) locus in lung cancers is a way these tumors evade the immune system and allow mutation expansion and branched evolution within tumor cells
Analysis of the human cancer glycome identifies a novel group of tumor - associated N - acetylglucosamine glycan antigens.
These results suggest that tumor antigen loaded CD40 - B may serve as a practical alternative to DC in cell - based vaccine strategies for both dogs and humans with cancer.