In an effort to overcome these limitations, a team
at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which
cells from a
human intestinal
cell line originally isolated from a
tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from
human blood vessel - derived endothelial
cells in the adjacent channel.
Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous
human tumor cell lines and xenograft models (including
human breast, prostate, and lung carcinoma)
at clinically achievable concentrations.