Sentences with phrase «human tumor cells»

In studies of laboratory - grown human tumor cell lines, the drug disrupted tumor cell division and prevented growth of advanced cancer cells.

The authors studied a standard panel of 60 established human tumor cell lines representing nine different human cancers, as well as several specimens of human primary ovarian cancer.

Evidence demonstrating its cytostatic activity includes the finding that it inhibits the growth of a broad spectrum of human tumor cell lines in vitro.

The title of her seminar was «Drug Discovery Efforts in the Reactivation of Mutant p53 in Human Tumor Cells.»

However, Stein says that more experiments are necessary with grafts of human tumor cells into animal brains first.

They then tested the behavior of human tumor cells with and without HOXA5 by injecting those cells into the mammary fat pad of mice.

Kilian said his team's synthetic microenvironment lies somewhere in the middle of two extremes in the field of modeling biology: the hard plastic plate, and expensive mouse avatars that are created by injecting human tumor cells into mice.

This week, Fior, who is at the Champalimaud Centre for the Unknown in Lisbon, and her colleagues reported growing implanted human tumor cells in zebrafish larvae.

Josef Singer and Judith Fazekas, both lead authors of the study, discovered that a receptor frequently found on human tumor cells (epidermal growth factor receptor or EGFR) is nearly 100 percent identical with the EGF receptor in dogs.

In an animal model for glioblastoma in which human tumor cells are grown in a mouse's flank, treatment with coibamide A significantly reduced tumor size.

The assembly and analysis of human tumor cell genomes, many of which contain chromosome deletions, duplications and insertions, as well as single nucleotide changes, requires immense data storage capacity and high - speed computation.

Flavopiridol inhibits several cellular kinases and has demonstrated cytostatic and cytotoxic activity in vitro and in vivo in numerous human tumor cell lines and xenograft models (including human breast, prostate, and lung carcinoma) at clinically achievable concentrations.

In addition, ActD has been shown to mimic nutlin - 3 in the activation of p53 - dependent transcription, induction of a reversible protective growth arrest in normal cells, and enhancement of the activity of the chemotherapeutic drugs, melphalan and etoposide, resulting in apoptosis of p53 positive human tumor cells [14].

«Flavonoids and Vitamin E Reduce the Release of the Angiogenic Peptide Vascular Endothelial Growth Factor from Human Tumor Cells».

They already knew of one such compound, a chemical called PD09859 that is one of 60,000 agents the NCI had screened for ability to block growth of human tumor cells.

Published in Molecular Neurobiology, the study led by Dr Elodie Siney under the supervision of Dr Sandrine Willaime - Morawek, Lecturer in Stem Cells and Brain Repair at the University, analysed how enzymes called ADAMs affect the movement and function of the human tumor cells.

Human tumor cells (red) growing in a zebrafish embryo may help doctors choose how to treat cancer patients.

However, some human tumor cells may also be hard to infect with viral therapies, Dr. Cripe reasoned, and knowing how cells respond in those situations could also be important to improving cancer treatments.

Specifically, they looked for the ability of those compounds to interfere with transcription in human tumor cells obtained through the National Cancer Institute's collection of 60 human tumor cell lines of nine different cancer types, including melanoma and colon cancer.

He surmised that human tumor cells grown in a living, breathing mouse, instead of a dish, would be more likely to predict the drug response of an actual human tumor.

Peter and colleagues focused their initial studies on a standard panel, known as NCI60, of 60 human tumor cell lines that can genetically be divided into two large groups, which they called superclusters 1 and 2.

This provided the first evidence that genes injected directly into human tumor cells can take hold, function and stimulate the immune system without toxicity.

Previously, she developed an innovative High Content Screening HTS platform, OncoPanel, to profile therapeutic cancer agents across 240 human tumor cell lines at Ricerca Biosciences (formerly MDS Pharma Services).

In the NCI tumor cell line panel, flavopiridol had significant inhibitory activity against all of the more than 60 human tumor cell lines with no clear selectivity for tumor type.

What are the molecules that determine why a human tumor cell migrates to and survives in a different organ — a different environment with different growth factors, adhesion molecules, hormones, and glandular products nearby?»

Randa's research involved synthesizing compounds that reactivate mutant p53 in human tumor cells and developed assays that measure a compound's in vitro human metabolic rate and the ability of the compounds to cross the blood brain barrier.