His laboratory develops and deploys new biochemical and computational methods in functional genomics, to elucidate the genetic basis of
human disease and
human physiology, and to create and deploy novel techniques in next - generation sequencing and algorithms for
tumor evolution, genome
evolution, DNA and RNA modifications, and genome / epigenome engineering.
Revealed that the loss of the
human leukocyte antigen (HLA) locus in lung cancers is a way these
tumors evade the immune system and allow mutation expansion and branched
evolution within
tumor cells