The results of a study of more than 100
human tumor samples show that the tumors expressing a high level of CCR3 present more frequent local dissemination.
Not exact matches
To determine how the cells switch from one type to another, they took three
human uterine carcinosarcoma
samples and sequenced the genomes of cells in two parts of each
tumor: the carcinoma and sarcoma components.
HBI member V. Wee Yong, PhD and research associate Susobhan Sarkar, PhD, and their team including researchers from the Department of Clinical Neurosciences and the university's Southern Alberta Cancer Research Institute, looked at
human brain
tumor samples and discovered that specialized immune cells in brain
tumor patients are compromised.
To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in
samples from six early - stage
human tumors.
To that end, in collaboration with the University of Zurich and MD Anderson Cancer Center, the researchers tested melanoma
tumor samples from
human patients undergoing treatment with the same targeted therapies.
To streamline this process, Uhlén's team has created standardized arrays containing microscopic
samples from 48 kinds of normal
human tissue and 20 types of
tumors.
The researchers next will turn to analyzing the presence of myoferlin in
samples from numerous
human tumor types available in an Ohio State tissue bank, which will allow them to compare protein levels in
tumors to clinical outcomes for the patients who provided the
samples.
The Ogretmen laboratory screened previously reported microarray data sets of several
human tumor tissues (metastatic head and neck squamous cell carcinoma, melanoma, and renal cell carcinoma) and showed that, in these
samples, only the levels of CerS4 were significantly decreased.
The research team analyzed BRAF inhibitor resistance in melanoma cell lines, mice bearing
human melanoma
tumors, and in
human tumor biopsy
samples.
They then conducted biochemical analyses to identify neuroligin - 3, confirm that the protein could stimulate
tumor growth in cultured
samples of several kinds of
human high - grade gliomas and study which signals the protein uses within glioma cells to promote their growth.
Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary
tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of
human breast cancer.
As a next step, Guha, Avadhani and colleagues plan to extend this study to in vivo mouse models and will also investigate these mechanisms in
tumor samples from
human breast cancer patients.
In a series of lab experiments with cell lines,
human xenograft
tumors in mice and primary
human prostate cancer
samples, the researchers demonstrated that miR - 34a inhibits prostate cancer stem cells by suppressing CD44.
Immunoblot analysis using mouse monoclonal antibody to
human IgM detected IgM to cytomegalovirus (CMV)- specific proteins (150, 42, 38, 32, and 28 kDa) in 74 (38 %) of 197 seropositive serum
samples from 197 individuals in three subject groups: 43 surgical patients, 31 patients with solid
tumors, and 123 healthy individuals.
To develop the methodology, the group analyzed the molecular profiles of
human embryonic stem cells and compared them with data for 12,000
samples of 33 different
tumor types held by The Cancer Genome Atlas (TCGA), a U.S. public database.