Sentences with phrase «human tumors using»

Not exact matches

I am unsure why you disagree with using data / results from studying other animals that are known to be similar to humans — I see studies all the time that correlate results in other species (eg, to demonstrate the carcinogenic properties of something, they give it to rats and watch for tumors).

Using human - derived glioblastoma cells in a mouse models, researchers found that the modified high - fat, low - carbohydrate diet increased life expectancy by 50 percent while also reducing tumor progression by a similar amount.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

The first - in - human PET / CT imaging of 75 patients with 18F - MPG was performed to show that this tracer can be used as a companion diagnostic to identify NSCLC patients with EGFR activating mutant tumors (primary tumor or metastatic) with 84.3 % accuracy.

Cheng and colleagues did experiments using human cells and identified hnRNPM's role in controlling the processes linked to tumor metastasis.

Tamayo and team tested REVEALER using The Cancer Genome Atlas (TCGA), the National Institutes of Health's database of genomic information from more than 500 human tumors representing many cancer types.

The researchers first used yeast to quickly and cheaply screen 169,000 interactions between yeast versions of human tumor - suppressor genes and genes that can be inhibited with drugs, sometimes called «druggable» targets.

To see if PGD and the pentose phosphate pathway were tied to the epigenetic changes the researchers had detected in distant metastases, they treated tumor cells from different sites in a single patient with the drug 6 - aminonicotinamide (6AN), which is known to inhibit PGD but is not used in humans because of its severe side effects.

This group's achievement shows the possibility to clarify the mechanism of human tumor formation, especially the molecular mechanism responsible for in the initial stage of cell cancerization due to DNA damaged by radiation in the initial stage, by using the model of budding yeast, a primitive eukaryote.

As proof - of - principle of the potential efficacy, Zhang's team grew human ovarian tumors in immunocompromised mice, then injected short - interfering RNAs to block the tumors» growth using RNA interference against FAL1.

By using molecular genetic tools to reduce the amount of PC in human lung cancer cells, the team observed decreased cell growth, a compromised ability to form colonies in soft agar (a gelatinous material specifically used to grow bacteria and other cells), and a reduced rate of tumor growth in mice.

«The use of a mouse tumor - derived matrix would limit any future applications of these organoid technologies in humans, and this work opens the door to research directed specifically for clinical applications,» noted Asma Nusrat, study co-author and the Aldred Scott Warthin Professor and Director of Experimental Pathology in the University of Michigan's School of Medicine.

But because the human eye isn't sensitive to near - infrared light, surgeons have to use a special camera to see the glow and identify the tumor's precise location.

They then conducted biochemical analyses to identify neuroligin - 3, confirm that the protein could stimulate tumor growth in cultured samples of several kinds of human high - grade gliomas and study which signals the protein uses within glioma cells to promote their growth.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

Human breast tumors transplanted into mice are excellent models of metastatic cancer and are providing insights into how to attack breast cancers that no longer respond to the drugs used to treat them, according to research from Washington University School of Medicine in St. Louis.

So - called cancer immunotherapy — which is the treatment of tumors by the use of antibodies — has been established and used very successfully in human medicine for about 20 years.

Using tumor models for both astrocytoma and oligodendroglioma, which are very similar to human tumors, they could show that one and the same cell type, called oligodendrocyte precursor cells, could give rise to both tumor forms.

Using cultured cells derived from human tumors of the breast and prostate gland, they confirmed that the IL6R / STAT3 / miR -34 a feedback loop is also activated in other tumor types.

Using the gene - editing system known as CRISPR, MIT researchers have shown in mice that they can generate colon tumors that very closely resemble human tumors.

Researchers used the mice to show that pemetrexed and gemcitabine worked against human group 3 tumors and that the drugs could be used in combination with existing chemotherapy agents to boost treatment effectiveness without undue risk.

Palanichamy, Chakravarti and their colleagues conducted this study using 13 primary GBM cell lines derived from patient tumors, four commercially available GBM cell lines and normal human astrocyte cells.

«Simple sugar used to detect human brain tumors.»

«For the first time, we were able to directly monitor oxygen levels in human tumors growing in a mouse brain using EPR oximetry with implantable resonators,» explained Khan.

Past clinical trials of stem cell therapies for chronic stroke patients used cells derived from tumors in humans and brain tissue from fetal pigs.

↵ 3 The abbreviations used are: HUVEC, human umbilical vein endothelial cell; DiI - Ac - LDL, 1,1 ′ - dioctadecyl - 3,3,3 ′, 3 ′ - tetramethyl - indocarbocyanine acetylated low - density lipoprotein; FACS, fluorescence - activated cell sorting; FGFR, fibroblast growth factor receptor; Flk, fetal liver kinase; ICAM, intercellular adhesion molecule; mAb, monoclonal antibody; PE, phycoerythrin; TNF, tumor necrosis factor; VCAM, vascular cell adhesion molecule.

Some examples from their lab include using AAV to introduce epitope tags into the endogenous alleles of the p53 and PTEN tumor suppressor genes in human cells (Kim et al 2008).

They have also used AAV gene editing to introduce naturally occurring cancer - causing mutations into the endogenous allele of the STAG2 tumor suppressor in human cells -LRB-

They have also used AAV gene editing to introduce naturally occurring cancer - causing mutations into the endogenous allele of the STAG2 tumor suppressor in human cells (Kim et al, 2016).

Nagrath, who directs Rice's Laboratory for Systems Biology of Human Diseases, found that some cancer cells are capable of using these information packets as a source of energy to fuel tumor growth.

In a 1988 paper summarizing his findings, Fiebig concluded that xenograft mice were wonderful models for broadly testing new drugs against human tumors, but they «can not be used as a clinical routine method» for predicting patient treatment.1 The idea of using xenograft mice as personal avatars for cancer patients was discarded.

Researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine have discovered a peripheral biomarker in human blood serum that can be used to detect the presence and progress of glioblastoma brain tumors before and after treatment.

Furthermore, many PMA - stimulated secreted proteins are expressed in a range of human cancers — an interesting finding, considering the HMEC line used for the studies is incapable of producing tumors.

Using 80 of the successful tumor xenografts — from the Greek «xenos» meaning «foreign» — he compared how the mouse's tumor responded to a drug or drug combination with the treatment response of the corresponding human patient.

We chose this model because 1) it more closely recapitulates features of human pancreatic cancer than do s.c. - implanted tumors, 2) it can be used in immunocompetent mice to permit assessment of immune responses, and 3) the cells grow in vivo with predictable kinetics (34).

Lloyd Old, Thierry Boon, and colleagues develop the TNF release assay for mouse systems in which release of TNF by T cells could be used to assess specific T cell recognition, facilitating the cloning of human tumor antigens.

We are using mouse models in conjunction with human tissue analysis to understand how this fibrosis arises and how it can be altered to allow access of chemotherapeutic agents to the tumor.

The laboratory of Vincenzo Cerundolo is the first group to report the use of tetrameric soluble class I / peptide complexes (tetramers) for the identification of tumor - specific cytotoxic T lymphocytes (CTLs), and subsequently shows that these novel reagents allow rapid and accurate analysis of human CTL responses.

The critical roles of tumor - initiating cells and the lymph node stromal microenvironment in human colorectal cancer extranodal metastasis using a unique humanized orthotopic mouse model.

Mouse mammary tumor virus uses mouse but not human transferrin receptor 1 to reach a low pH compartment and infect cells.

Tumor Paint is not yet in human use but is being developed by Blaze Bioscience, a Seattle biotech founded by Olson and Heather Franklin, president and chief executive officer.

Secondly, before considering the use of iPSC - derived organoids for transplantation / regenerative medicine in human patients, the current protocols for expansion, reprogramming and differentiation of iPSCs in long - term cultures need further improvement to minimize the risk of oncogenic cellular mutations and teratoma, or tumor formation, in the patient.

He and the Vereide Group grow precursors of human arterial cells, build colonies of dendritic cells (cells which can alert the rest of the immune system to the presence of a tumor), and use chick embryos to study the formation of early tissue layers for a possible future in which complex tissues, or even organs, can be grown to replace diseased, wounded, or malfunctioning ones.

The drugs were chosen because they were thought to have possible effects against brain tumors and were already used in humans or were being developed for human use.

Immunoblot analysis using mouse monoclonal antibody to human IgM detected IgM to cytomegalovirus (CMV)- specific proteins (150, 42, 38, 32, and 28 kDa) in 74 (38 %) of 197 seropositive serum samples from 197 individuals in three subject groups: 43 surgical patients, 31 patients with solid tumors, and 123 healthy individuals.

A genome - wide study of allelic imbalance in human testicular germ cell tumors using microsatellite markers.

Using human colon cancer cells and primary human fibroblasts isolated from tumors and adjacent normal tissues, Alexandros Glentis and colleagues at the Institut Curie addressed the question of whether the cancer cells or the CAF cells were responsible for the breakdown of the basement membrane that leads to cancer progression.

Using assembly - based whole - genome DNA sequencing, we found previously undefined genomic rearrangements in human rhabdoid tumors.

Dr. Mack's research has focused primarily on the use of novel antitumor agents in human estrogen receptor negative breast tumor cells, and more recently, on the use of bioflavonoids in the regulation of estrogen receptor positive (ER +) and estrogen receptor negative (ER --RRB- breast tumor cell proliferation.