Initially, the Geneva researchers observed the vascularisation processes of
human tumour cells from different cell lines.
The researchers studied tumour tissue from patients, cultivated
human tumour cells and tumours in mouse models for neuroblastoma.
The study, which is published in the journal Nature Communications, was conducted on
human tumour cells and on mice, and offers hope of a much improved therapy for a severe form of cancer.
Not exact matches
The team found that exposing samples of
human glioblastoma
tumours grown in a dish to the Zika virus destroyed the cancer stem
cells.
A DEVICE that filters cancer
cells from
human blood using sound could help to identify
tumour cells that have spread.
Rodríguez - Perales, Torres and Ramírez have shown that by transferring the RGEN components into primary
human cells, regions of the exchanged chromosomes in some
tumours can be marked, thus generating cuts in those chromosomes.
The researchers hope that ultimately
human trials will prove the efficacy of the OH14 compound in sensitising
tumour cells and cancer stem
cells to existing drug - based therapies thus disabling
tumours from seeding new growth after treatment.
Cell lines from
human tumours did exist, but were considered unsafe: what if cancerous
cells were transferred along with the vaccine?
«Shutting off vital
tumour growth processes can lead to the death of
human brain
tumour - initiating
cells.
Lead author Moustafa Abdalla writes: «Almost all genomic studies of breast cancer have focused on well - established
tumours because it is technically challenging to study the earliest mutational events occurring in
human breast epithelial
cells.»
They placed the
human cancer
cells into the incubator and lowered the oxygen to a level comparable to that in a
tumour.
The existence of cancer stem
cells has already been reported in a number of
human cancers, explains Professor Jacobsen, but previous findings have remained controversial since the lab tests used to establish the identity of cancer stem
cells have been shown to be unreliable and, in any case, do not reflect the «real situation» in an intact
tumour in a patient.
They turned to cultured
cells derived from
human lung
tumours.
Experimental models include yeast, mammalian and
human cell lines, mutant mouse models and
tumour samples.
Discovery of synonymous cancer driver mutations in
human tumours associated with changes in the splicing of oncogenes (Lehner group,
Cell 2014).
His research interests have included the immunogenetics of diabetes, the biology of
tumour - associated antigens and
cell adhesion molecules, and ethical aspects of the design of trials involving
human subjects.
Tumours develop from normal
human cells through a complex process with multiple stages.
Read two parallel stories about half a million
human immune
cells and
cells from a mouse
tumour model and
human spleen.
The meeting will also feature other aspects of the
Human Cell Atlas initiative, including updates on progress so far towards atlases of
tumour, lung, gut, kidney and immune system
cells.
Prom1 was reported recently to mark cancer stem
cells of
human intestinal
tumours that arise frequently as a consequence of aberrant wingless (Wnt) signalling.
On the basis of studies on the XMRV - producing
human prostate cancer
cell lines CWR22Rν1 and CWR - R1 and their progenitor
tumour xenograft CRW22, they concluded that XMRV infections were caused by contamination during in vivo passaging in nude mice.
Expression of oncogenic β - catenin in Sox2 + young adult pituitary stem
cells leads to formation of clusters of stem
cells and induction of
tumours resembling
human adamantinomatous craniopharyngioma (ACP), derived from Sox2 -
cells in a paracrine manner.
Senoo M, Tsuchiya I, Matsumura Y, Mori T, Saito Y, Kato H, Okamoto T, Habu S. Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in
human squamous
cell carcinomas: expression of Delta Np73L, a novel dominant - negative isoform, and loss of expression of the potential
tumour suppressor p51.
The Journal of Agricultural and Food Chemistry had on its December 2006 issue a report that found the ability of red raspberries to repress the
human oral and breast, as well as colon and prostate
tumour cell lines growths when they were tested in test tubes.
But until now how the
tumour cells affect and influence the surrounding tissue between dogs and
humans has been unknown.
From the dogs» samples, researchers were able to prove that some
cells in the vicinity of
tumours act the same way as the
cells would, in similar circumstances, behave in
humans.