There was
a human vaccine for Lyme disease until 2002 when it was discontinued.
A research team at The University of Texas at El Paso is one step closer to developing an effective
human vaccine for cutaneous leishmaniasis, a tropical disease found in Texas and Oklahoma, and affecting some U.S. troops stationed in Afghanistan and Iraq.
Not exact matches
So far, Inovio has made the most progress with a so - called therapeutic
vaccine — one that helps defeat a disease even after a patient has been diagnosed —
for human papilloma virus, or HPV.
There are currently two types of cancer
vaccines available: preventive,
for human papillomavirus and hepatitis B; and treatment,
for metastatic prostate cancer.
«We are honored to receive this award which underscores the unique value of our technology platform and its game changing potential to make novel
vaccines for important
human diseases.»
The only two manufacturers of
human rabies
vaccine approved
for use in the U.S. have experienced production interruptions and other problems that could result in a shortage, health officials warn.
Multiple obstacles stand in the way of this becoming a future universal flu
vaccine for humans, scientists from The Scripps Research Institute cautioned in an accompanying commentary in Science.
The company has begun
human testing of its mRNA drugs
for cardiovascular disease and cancer, and
for vaccines against the flu, Zika, and chikungunya viruses.
The pEpitope method accounts
for 77 percent of what impacts efficacy of the
vaccine in
humans.
In all environments and independent of the resource settings, two doses of
human papillomavirus
vaccine are recommended
for girls ages 9 to 14 years, with an interval of at least 6 months and up to 12 to 15 months between doses.
This finding also paves the way
for practical applications: the ETH spin - off Malcisbo, which came from the microbiologist's laboratory, endeavours, on the basis of these surface sugar structures to develop novel
vaccines against parasites and pathogenic germs
for livestock and
humans.
«Study offers new recommendations
for TB
vaccine testing in
humans.»
Furthermore, there is no DNA
vaccine currently licensed
for use among
humans.
And by winter several more
vaccine candidates that employ various forms of the virus are slated
for human testing, supported by funds from the NIH.
Vaccines developed using proteins rather than live viruses can help protect animals and subsequently humans from insect - borne viruses, according to Alan Young, chief scientific officer for Medgene Labs, an animal health company that develops therapeutics and diagnostics, including v
Vaccines developed using proteins rather than live viruses can help protect animals and subsequently
humans from insect - borne viruses, according to Alan Young, chief scientific officer
for Medgene Labs, an animal health company that develops therapeutics and diagnostics, including
vaccinesvaccines.
An NIH - backed
vaccine is among several heading
for human trials, but the timeline
for large - scale deployment remains murky
In response to the Ebola Zaire outbreak, several of these
vaccines have been fast tracked
for human use.
Yet there is reason
for optimism: the NIH has already developed a DNA
vaccine against the West Nile virus that appeared promising in early
human studies (although ultimately the NIH could not find a commercial partner to take that
vaccine forward).
Roughly a year after Brazilian doctors and researchers first suspected a link between a spate of alarming birth defects and the Zika virus, a cadre of potential
vaccines are now headed
for testing in
humans.
Last year alone, the US Department of Health and
Human Services allocated $ 400 million to three centres
for producing
vaccines against potential bioweapons.
The first
vaccine to receive the green light
for human trials is a product from Pennsylvania - based Inovio Pharmaceuticals.
Injectable
vaccines often require trapping the animal — a costly endeavor that's stressful and dangerous
for both wild animals and the
humans doing the vaccinating.
Unlike any other
vaccine designed
for human use, this product would be a DNA
vaccine that only contains a particular part of the pathogen (rather than a
vaccine with an inactivated live or dead virus,
for example).
No drugs or
vaccines are yet available
for human use.
Merck has developed a
vaccine for human papillomavirus, the leading cause of cervical cancer.
Understanding what combination of mutations could transform H5N1 into a
human pandemic virus gives epidemiologists a leg up on preparing countermeasures; they can,
for example, test existing
vaccines against the new strain.
Every year, public health officials survey the three flu subtypes circulating in
humans and design a
vaccine for the next winter season that covers them all.
«
For instance, diagnostic tests could be tailored to different strains or stages of the disease,» and
vaccines could be designed to skirt interaction with the
human body.
For their research, Pekosz and his team, using
human nasal tract cells, studied the weakened strain of the flu virus that is used in the nasal spray
vaccine and compared its behavior with that of the flu virus itself.
In September, Roswell Park Cancer Institute in New York and Cuba's Center
for Molecular Immunology announced that they would partner to test a cancer
vaccine, said Cristina Rabadán - Diehl, director of the Office of the Americas in the Office of Global Affairs, Office of the Secretary at the U.S. Department of Health and
Human Services.
Kristien Van Reeth, of Belgium's Ghent University, and collaborators are comparing different
vaccines and vaccination strategies in swine, which are used as a model
for humans.
Researchers from the University of Zurich and University Hospital Zurich now reveal which factors are responsible
for the
human body forming such broadly neutralizing HIV antibodies, thereby opening new avenues
for the development of an HIV
vaccine.
«Several letters [from the Association of American Medical Colleges and others]... suggest that
human fetal tissue is used
for modern
vaccine production.
According to a study published in
Human Vaccines & Immunotherapeutics, the Tdap
vaccine is safe
for both mothers and infants.
The rationale
for sequencing and exploring the
human genome — to revolutionize the finding of new drugs, diagnostics and
vaccines, and to tailor treatments to the genetic make - up of individuals — is the same today.
Testing on chimps has been a huge boon
for humans in the past, contributing to the discovery of hepatitis C and
vaccines against polio and hepatitis B, among other advances.
The team was led by Barton Haynes, M.D., director of the Duke Center
for HIV / AIDS
Vaccine Immunology - Immunogen Discovery (CHAVI - ID) and the Duke
Human Vaccine Institute, and John Mascola, M.D., director of the
Vaccine Research Center of the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Last year the National Institutes of Health announced plans to put some 180 ex-Coulston chimps currently housed at the Alamogordo Primate Facility back in service, to rejoin the roughly 800 other chimps that serve as subjects
for studies of
human diseases, therapies and
vaccines in the U.S., which is the only country apart from Gabon to maintain chimps
for this purpose.
No
vaccine currently exists
for HIV (
human immunodeficiency virus) and there is no cure
for AIDS (acquired immune deficiency syndrome), which currently infects 34 million around the globe.
This study strengthens the argument
for focusing on the malaria side of the parasite -
human interaction in our search
for new
vaccine candidates.»
Profectus BioSciences in Tarrytown, New York, which is developing a similar
vaccine, needs some $ 2 million to produce it under good manufacturing practice standards, a prerequisite
for any
human study.
Ding's next goal is to raise $ 5 million so he can spend about five years studying new
vaccines for human pathogens such as dengue fever.
Vaccines have treated infectious prions in mice, raising hopes of a cure
for the deadly
human version of «mad cow disease».
Adenovirus 5 has 50 or so known relatives that infect
humans and so in principle could also be used as a basis
for vaccines, as could one from a chimpanzee.
Currently, there is no
vaccine for the disease in
humans.
After the European Medicines Agency's Committee
for Medicinal Products
for Human Use meeting 19 - 22 October, the agency recommended that everyone regardless of age receive two doses of the pandemic flu
vaccines approved
for use there.
«Given that approximately 12 percent of
human cancers worldwide may be attributed to viruses, and there are no
vaccines currently available
for these five viruses, prevention strategies to reduce the infections that can lead to cancer are even more critical,» said Linda Birnbaum, Ph.D., director of the National Institute of Environmental Health Sciences (NIEHS) and National Toxicology Program (NTP).
Human safety trials
for a
vaccine to jump - start immunity could begin later this year; larger efficacy trials may be a year and a half away.
A new experimental
vaccine for Ebola is currently undergoing testing in a global clinical trial in
humans.
Because there is no
vaccine for humans, efforts to curb the disease's spread focus on controlling mosquitoes and their infection rates.