While the basic cellular organization of the cortex in
humans and mice looks the same, Rakic states, «the connections are different, the functionality is different.»
Not exact matches
The
mice behaved just like others of their kind, as far as scientists could tell,
and they also
looked the same — except for the
human mini brain that had been implanted into each rodent's own cortex, made visible by a little clear cover replacing part of their skull.
The book
looks at fish that live in subfreezing waters, ruminating monkeys, ridiculously poisonous newts, birds that see in the ultraviolet,
mice that live on lava flows, cave fish, coelacanths, bush babies,
humans,
and some other marvels of evolution.
In addition to
looking at
mouse models of diabetes, the researchers also showed that exposure of
human pancreatic islet cells — both from healthy donors
and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.
«We identified that the peculiar
look of these naked lizards is due to the disruption of the ectodysplasin - A (EDA), a gene whose mutations in
humans and mice are known to generate substantial abnormalities in the development of teeth, glands, nails
and hairs», says Michel Milinkovitch.
«However, while these encouraging results in
mice mean that the zinc finger
looks like a good candidate to take forward to
human trials, we still need to do a lot of work first to answer important questions around the safety of the intervention, whether repeat treatments are effective, whether there might be longer - term side effects,
and whether we can extend
and increase the benefits beyond six months.
«If you're
looking for very specific molecular targets or pathways in the brain,
and how drugs might act on them, the difference between
human cells
and mouse cells is significant.»
In an extensive sleuthing expedition that
looked back nearly 20 years, two collaborating research teams contend that they have evidence that xenotropic murine leukemia virus — related virus (XMRV) resulted from the chance recombination of pieces of two
mouse viruses in lab experiments
and that the connections to
human disease are spurious.
«Importantly, we use
mice as models of
human beings in research,
and so when
looking for anti-obesity drugs, we need to fully understand the function of the NPY system in this animal model to understand how similar circuits in
humans connect with the body clock.»
Andrechek's federally funded study
looked at
mice containing all subtypes
and compared the makeup of the rodent tumors
and the way the genes acted, known as gene expression, to
human tumor data.
Looking across evolutionary time
and the genomic landscapes of
humans and mice, an international group of researchers has found powerful clues to why certain processes
and systems in the
mouse — such as the immune system, metabolism
and stress response — are so different from those in people.
Newcomb
and her colleagues
looked at
human and mouse cells to further study the trend in gender differences that they had observed.
Rats
and mice in pain make facial expressions similar to those in
humans — so similar, in fact, that a few years ago researchers developed rodent «grimace scales,» which help them assess an animal's level of pain simply by
looking at its face.
IN THE BEGINNING Early embryos (a four - cell embryo shown) from
mice and humans look the same on the outside, but gene activity studies show some big differences under the hood.
To determine the effect of gastric acid suppression on the progression of chronic liver disease, Schnabl's team
looked at
mouse models that mimic alcoholic liver disease, NAFLD
and NASH in
humans.
She
looked after her children during the first year
and took a postdoc on
mouse models of
human fertility in a genetics group at the Stanford School of Medicine in their second year in California.
In a new study published in the journal Genetics, evolutionary biologist Dominic Wright
and his team
looked at whether there's a genetic connection between anxious behavior in chickens,
mice and humans.
His plans for research in his own lab involve «continuing to
look at the mechanisms of T cell dysfunction in
human and mice.
Not so long ago, the advent of powerful genomic tools
and genetic engineering techniques made it seem that studies involving
mice engineered to carry
human disease genes would be the best approach for exploring
human disorders, superior to
looking at cells isolated in a laboratory.
By
looking at
and comparing the genomes of
humans,
mice, cows,
and two types of fish, these researchers were able to discern general patterns in what led to the emergence of new life forms in different time periods.
Initial studies
looking at fasting a few days before chemotherapy in
mice and dogs yielded positive outcomes, spurring small trials in
humans.
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Other studies are
looking at its role in improving cognitive function in
mice and humans.
We've
looked high
and low for great wireless
mice that work with the Chromebook, but we're only
human,
and we might have missed something super-amazing.