Sentences with phrase «humans and mice show»

Our data in humans and mice show that adipocyte size is a strong predictor of the percentage of macrophages in adipose tissue (Figure 3e).

Humans and mice show significantly different responses to arsenic, but the results are still important, says David Polya at the University of Manchester, UK, who was not involved in the work.

Not exact matches

Now, a new study of wild mice shows that they, too, can develop signs of domestication — white fur patches and short snouts — with hardly any human influence.

A study by researchers at the University of Chicago Medicine shows that when mice that are genetically susceptible to developing inflammatory bowel disease (IBD) were given antibiotics during late pregnancy and the early nursing period, their offspring were more likely to develop an inflammatory condition of the colon that resembles human IBD.

«Our study shows that epigenetic drift, which is characterized by gains and losses in DNA methylation in the genome over time, occurs more rapidly in mice than in monkeys and more rapidly in monkeys than in humans,» explains Jean - Pierre Issa, MD, Director of the Fels Institute for Cancer Research at LKSOM, and senior investigator on the new study.

«We've been hearing about their potential for more than a decade, but the results have always been in mice and rats, and no one has shown they're safe or effective in humans long term,» says Robert Lanza of Advanced Cell Technology in Marlborough, Massachusetts, the company that carried out the stem cell intervention.

Duke scientists have shown that it's possible to pick out key changes in the genetic code between chimpanzees and humans and then visualize their respective contributions to early brain development by using mouse embryos.

Although the researchers emphasized that laboratory results involving cell lines and mice do not necessarily translate to human treatment, they say their findings show that new mTOR inhibitors combined with chemotherapy could become a new treatment strategy for T - ALL.

University of California, Irvine neurobiologists Leslie Thompson and Joseph Ochaba with the Departments of Neurobiology & Behavior and Psychiatry & Human Behavior and their colleagues from UCI and from Children's Hospital of Philadelphia have shown that reducing the aberrant accumulation of a particular form of the mutant Huntingtin protein corresponds to improvement in symptoms and neuroinflammation in HD mice.

Senior author Madhav Dhodapkar, M.D., the Arthur H. and Isabel Bunker Professor of Medicine and Immunobiology, and chief of Hematology, said the study, using tissue and blood samples from humans and mice, shows that chronic stimulation of the immune system by lipids made in the context of inflammation underlies the origins of at least a third of all myeloma cases.

In experiments conducted on human lung endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which lines the walls of blood and lymph vessels.

Further research showed that fetal mice bred to lack these molecules — like animals lacking MHCI, and like humans with autism or schizophrenia — undergo inadequate synaptic pruning in some parts of their brains.

In addition to looking at mouse models of diabetes, the researchers also showed that exposure of human pancreatic islet cells — both from healthy donors and from patients with Type 1 diabetes — to fasting - mimicking diet in a dish stimulated insulin production.

Many PD patients typically show an increase in anxiety and depression, and in this respect the SNCA mouse model did not replicate the human condition.

The two reports also showed that Zika virus infected and damaged neuronal stem cells harvested from mice and humans.

Scientists have a promising new approach to combating deadly human viruses thanks to an educated hunch by University of California, Riverside microbiology professor Shou - Wei Ding, and his 20 years of research on plants, fruit flies, nematodes and mice to show the truth in his theory.

This take on Michelangelo's famous Sistine Chapel image symbolizes the link between human pain patients and the mouse model: The lab - designed SPR inhibitor (in green), shown within the active pocket of SPR itself (in gray with its atomic structure in colored lines), is the «bridge» between the two species.

The factor also protects proteasome function in human, mouse and yeast cells when challenged with various proteasome poisons, studies showed.

The results obtained by Afsaneh Gaillard's team and that Pierre Vanderhaeghen at the Institute of Interdisciplinary Research in Human and Molecular Biology show, for the first time, using mice, that pluripotent stem cells differentiated into cortical neurons make it possible to reestablish damaged adult cortical circuits, both neuroanatomically and functionally.

Before Katlyn showed up at NIH, the doctors there were already well prepared: They had inserted healthy human ADA genes into a modified mouse retrovirus — a type of virus that can enter human cells and transfer new genetic material right into the DNA strands in their nuclei.

In marked contrast to the widely held notion that the insulin - producing pancreatic beta cell loses function with wear and tear, the researchers now show that mouse and human beta cells are fully functional at advanced age.

Since CGP3466B has already been tested in phase II clinical trials to (unsuccessfully) treat Parkinson's disease and ALS, it is known to be safe for humans, but the researchers caution that many more years of studies are needed to definitively show whether it is effective for preventing cocaine damage, first in mice, then in humans.

Now, a new study in mice shows how a gene, called FOXP2, implicated in a language disorder may have changed between humans and chimps to make learning to speak possible — or at least a little easier.

Researchers then induced a disease in these mice that mimics human MS.. In one genetic group, both males and females fed a high salt diet showed worse clinical signs of the disease.

«These results are especially exciting because they show that we can take findings in the mouse and possibly apply them at the human patient population,» said Koenig.

A 2007 study co-authored by Small shows that exercise improves its function in both mice and humans.

Pasinetti has shown that polyphenols in red wine reduce cognitive decline — and may prevent it — in mice genetically altered to develop Alzheimer's; he hopes to prescribe red wine (and grape juice varieties) to humans in the future.

The mouse model mimics aspects of the infection in humans, with high levels of the virus seen in the mouse brain and spinal cord, consistent with evidence showing that Zika causes neurological defects in human fetuses.

The experimental drug J147 is something of a modern elixir of life; it's been shown to treat Alzheimer's disease and reverse aging in mice and is almost ready for clinical trials in humans.

Hair thinning in a human patient and mouse with inherited loss of function mutations in WNT10A is shown.

In the new study, Lipton and his colleagues used human stem cell and mouse models to show exactly how SNO can trigger cell death in Parkinson's disease.

For the animal study, the researchers separated 52 mice with colon cancer tumors into three groups, including a control group and groups that were fed either the grape compounds or sulindac, an anti-inflammatory drug, which was chosen because a previous study showed it significantly reduced the number of tumors in humans.

«Worms, mice, humans, and even fruit flies show similar effects of intoxication at similar alcohol concentrations,» he says, and human neurons contain a switch similar to that in C. elegans.

We also show that the strategy is effective in two additional mouse models, one representing acute infection in mouse cells and the other representing chronic, or latent, infection in human cells.»

In subsequent experiments, Pissios and colleagues found that NNMT correlated positively with Sirt1 and a healthy metabolic profile in mice, and also showed that humans with low cholesterol and low triglycerides exhibited high levels of NNMT and Sirt1 in their livers.

While these results have yet to be demonstrated in humans, recent research has shown that boosting tissue levels of NAD + can improve health and reduce metabolic complications in mice that have been fed a high - fat diet.»

Green fluorescent protein labeling allowed them to see the early development pattern and show that lncND, which ordinarily is not present in mice — lncND is present only in some primates including humans — had a functional effect on development.

The study, published Nov. 17 by Proceedings of the National Academy of Sciences, shows that triclosan causes liver fibrosis and cancer in laboratory mice through molecular mechanisms that are also relevant in humans.

Work in germ - free mice shows providing the right human microbial communities can restore growth, likely by restoring the proper connections between growth hormone and insulinlike growth factor 1.

Tests in mice and nonhuman primates had shown TGN1412 to be safe, but when it was injected into humans — in a dose less than 1/500 of what was given to monkeys — it caused a massive release of infection - fighting T cells that overstimulated the patients» immune systems, resulting in multiple organ failure.

Using all the existing data that was available, Andrechek, along with MSU doctoral student Daniel Hollern, analyzed 1,172 mouse mammary tumor samples from 26 different preclinical models and was able to compile one of the largest databases to show which strains of mice were best suited to study a particular type of human breast cancer.

A series of biological analyses of the mice with Tim - 1 and immune cells isolated from human donors showed that Ebola virus directly binds to T - cells through Tim - 1 protein binding and causes massive inflammation that thwarts the immune system.

Previous studies have shown the drug to be effective at spurring new bone growth in mice and in humans with osteoporosis, and a U-M research team believes that it may spur new growth in brittle bone disease patients as well.

The blue stains in these developing mice embryos show that the human DNA inserted into the rodents turns on sooner and is more widespread (right) than the chimp version of the same DNA, promoting a bigger brain.

The study, conducted in both human and mouse cells, shows that cancer genomes lose copies of repetitive sequences known as ribosomal DNA.

«Our work outlines the genetic similarities of the tissue and cells in different types of tumors and shows the strong relationships mice can have to other human cancers too.»

«We can only extrapolate to humans, but in the mouse, our data show that the whole process [of egg maturation] takes 18 to 20 days, and we can detect this asymmetry by the second or third day of the process.

They also showed that certain genes and elements are similar in both species, providing a basis to use the mouse to study relevant human disease.

Using a model of Parkinson's disease in which the toxin MPTP, made famous in book «The Case of the Frozen Addicts,» induces Parkinson's - like symptoms in humans and mice, Dr. Smeyne showed that mice infected with H1N1, even long after the initial infection, had more severe Parkinson's symptoms than those who had not been infected with the flu.

«Previous studies in mice have indicated that bacteria that are able to encroach upon the epithelium might be able to promote inflammation that drives metabolic diseases, and now we've shown that this is also a feature of metabolic disease in humans, specifically type 2 diabetics who are exhibiting microbiota encroachment.»