Sentences with phrase «humans and mice with»

Genetic studies in humans and mice with idiopathic epilepsy have revealed a number of causative genes for specific forms of epilepsy 31.

In both humans and mice with lupus, groups of B lymphocytes (B cells) spontaneously arise in the absence of a pathogenic infection.

To make this discovery, the researchers stimulated isolated neutrophils from humans and mice with nicotine and could measure a dose - dependent release of inflammatory molecules.

Not exact matches

Scientists know how to make fruit flies and mice smarter, and efforts to come up with a treatment for Alzheimer's and other neurological disorders are leading to drugs that enhance memory and cognition in humans.

Humans are not sterile mice, after all, and we all start with our own unique mix of bacteria swirling around.

Researchers have injected mice with human breast, ovary, colon, bladder, brain, liver and prostate tumors, and their new drug has killed the tumors every time.

In order to determine the lethal toxic level of capsaicinoids in animals, and to extrapolate that level for humans, researchers in 1980 performed a rather gruesome experiment with mice, rats, guinea pigs and rabbits.

The study found that mice with peanut allergies developed similar symptoms as humans, notably itchy skin and breathing issues.

Hassles such as buying paper towels or searching for the perfect used car that used to require legwork, human interaction, and possibly even wearing pants can now be done with a click of a mouse from one's own living room.

The team found neonatal mice with the mutations had normal - appearing skin, and the dry itchy skin of dermatitis did not develop until the mice were a few months old, the equivalent of a young adult in human years.

Depending on results from further behavioural studies in mice and humans, the abnormalities could then be treated in parallel with seizures.

Much of their work focuses on the house mouse (Mus musculus), which evolved to be commensal with humans: The mice are not domesticated like dogs or sheep, but they are dependent on living in and around a human settlement.

«Apart from humans and some domestics that humans brought with them, mice are the most globally distributed mammals,» he says.

Compared with mice with cells from healthy people as well as non-chimera mice, those whose brains had human schizophrenia cells were more afraid to explore a maze, more anxious, more antisocial, less able to feel pleasure (from sipping sugar water), worse at remembering, and more sleepless — all of which characterize people with schizophrenia, too.

Now, a new study of wild mice shows that they, too, can develop signs of domestication — white fur patches and short snouts — with hardly any human influence.

To better understand their findings, the team examined the animal model for APS1 (i.e. mice with the same genetic defect as human patients with the syndrome) and found that male mice spontaneously developed an inflammatory disease in their prostate glands — a so - called prostatitis — and reacted to transglutaminase 4.

They seeded mice with human pancreatic tumours and then injected them daily with the souped - up bacteria for a week, giving them a week off before four more days of injections.

First mouse cells were turned into «totipotent» stem cells, and now early work suggests the same might have been achieved with human cells

Researchers at Weill Cornell Medical College recently identified a gene abnormality that is associated with anxiety - related behaviors; it makes humans and mice hypervigilant to cues that signal danger.

Shukla and colleagues discovered that a small drug molecule called BX795, which is sold to labs for use in experiments, helped clear HSV - 1 infection in cultured human corneal cells, in donated human corneas, and in the corneas of mice infected with HSV - 1.

What's more, an ointment containing the peptide effectively treated wounds infected with methicillin - resistant Staphylococcus aureus (MRSA) and the increasingly common hospital infection bacterium Acinetobacter baumannii in mice and on laboratory samples of human skin.

Recent collaborative work between UCR and Cedars - Sinai Medical Center in Los Angeles demonstrated that in animal models of human breast cancer, mice treated with 123B9 that was conjugated with paclitaxel had significantly fewer circulating cancer cells in the blood compared to mice that were not treated or even treated with paclitaxel alone.

These four genes and their proteins constitute the heart of the biological clock in flies, and with some modifications they appear to form a mechanism governing circadian rhythms throughout the animal kingdom, from fish to frogs, mice to humans.

Fat mice and humans have a less diverse milieu of gut bacteria, with a greater proportion of Firmicutes to Bacteroidetes in their bowels.

Then the team injected the mice with human liver cells and withdrew the drug.

To see whether this also applies to humans, the team engineered stem cells from people with and without Down's syndrome and injected them into mice.

To investigate, Walker Jackson of the Whitehead Institute in Boston, Massachusetts, and his colleagues created mice with a mutation associated with the human prion disease Fatal Familial Insomnia and injected some of their brain tissue into the brains of mice without the mutation.

The «training data» were generated from 78 mice infected with influenza or the cytomegalovirus (CMV) and 32 humans infected with flu, CMV or the Epstein - Barr virus.

This age period is associated with a decline in reproductive function and egg quality in both humans and mice.

Like the Rosetta Stone that scholars used to decode hieroglyphics, researchers trained the algorithm with more than 4,600 T cell receptors and then used it to correctly assign 81 percent of the human T cells and 78 percent of mouse T cells to one of 10 different viral epitopes.

«So far, the drug has only been tested in mice, and while some research in human genetics suggests this approach could work in people too, we need more research before we know how relevant this could be for people with type 2 diabetes.»

Shih, Wang and their colleagues tested fostamatinib's power to reduce tumor size in mice implanted with human ovarian cancer cells that were resistant to paclitaxel.

An inflammatory protein that triggers a pregnant mouse's immune response to an infection or other disease appears to cause brain injury in her fetus, but not the premature birth that was long believed to be linked with such neurologic damage in both rodents and humans, new Johns Hopkins - led research suggests.

Using the modified system, human melanoma and breast cancers as well as mouse melanoma cells were diagnosed with greater ease and efficiency.

So he implanted various human tumors — including ovarian, breast, colon, liver, and brain — into mice and then injected the animals with antibodies that disable CD47.

Even the new studies clashed somewhat: Unlike the UCSF study, the German research found no major differences between the overall microbiomes of twins with and without MS. Finally, mouse models of MS are not perfect mimics of the human disease, and mouse immune systems aren't identical to people's.

Like the per gene, the new genes — dubbed RIGUI in humans and m - rigui in mice — are turned on and off in a daily cycle and may work with other genes to generate the oscillating mechanism that runs the internal clock.

Although the researchers emphasized that laboratory results involving cell lines and mice do not necessarily translate to human treatment, they say their findings show that new mTOR inhibitors combined with chemotherapy could become a new treatment strategy for T - ALL.

University of California, Irvine neurobiologists Leslie Thompson and Joseph Ochaba with the Departments of Neurobiology & Behavior and Psychiatry & Human Behavior and their colleagues from UCI and from Children's Hospital of Philadelphia have shown that reducing the aberrant accumulation of a particular form of the mutant Huntingtin protein corresponds to improvement in symptoms and neuroinflammation in HD mice.

An unknown component of breast milk appears to kill HIV particles and virus - infected cells, as well as blocking HIV transmission in mice with a human immune system.

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

In addition, they injected mice with human cancer cells and found that the tumors grown in mice could be inhibited with PD173074.

Géléoc and colleagues at Boston Children's Hospital studied mice with a mutation in Ush1c, the same mutation that causes Usher type 1c in humans.

The scientists have detailed the functional parts of the mouse genome and have compared them with those in humans.

The research team also tried the GD2 CAR - T therapy in mice with human spinal cord and thalamic tumors implanted in their respective anatomical locations.

The mouse telomerase RNA component was cloned and contained only 65 percent sequence identity with the human telomerase RNA.

«Our results indicate that the epigenetic modification we studied makes both mice and humans more susceptible to obesity and with increasing age increases their risk of developing a fatty liver,» said Anne Kammel, first author of the study.

Part of the problem, he says, is that the incidence of many human chronic diseases rises with age, yet many researchers prefer using young mice because of the pressures of being published and getting funding.

Professor Chayama and his research group used mice with «humanized» livers, and injected them with human blood.

In the past, a drug's efficacy would often be measured with one test in mice and another in humans.