Researchers led by Prof. Torsten Ochsenreiter of the Institute of Cell Biology at the University of Bern have studied the mitochondria, the «power plants» of single - cell trypanosomes, and have now discovered that these behave differently from cell power plants in
humans during cell division.
Not exact matches
This new insight into how chromosomes are disassembled and reassembled
during cell division will allow researchers to begin answering basic questions about epigenetic inheritance, as well as
human disease such as chromosome disorders and cancer.
Paulo Navarro - Costa, first co-author of this study and researcher at the IGC explains: «Similarly to
humans, fruit fly ovules also have a resting period
during meiosis — the specialized
cell division required for the formation of healthy reproductive
cells.
Where the second type of condensin, which is present in
humans and other multicellular organisms, binds
during cell division is another future line of inquiry.
The approach developed by the MGH team focuses on small areas of the
human genome — so - called polyguanine (poly - G) repeats that are particularly susceptible to mutation, with genetic «mistakes» occurring frequently
during cell division.
The team used ChromEMT to image and measure chromatin in resting
human cells and
during cell division (mitosis) when DNA is compacted into its most dense form — the 23 pairs of mitotic chromosomes that are the iconic image of the
human genome.
Such perfect
division depends on the position of the mitotic spindle (chromosomes, microtubules, and spindle poles) within the
cell, and it's now clear that
human cells employ two specific mechanisms
during the portion of
division known as anaphase to correct mitotic spindle positioning.
For a systems - level understanding of all crucial protein interactions
during cell division, we are combining automated single molecule calibrated imaging and computational data analysis with advanced machine learning and modelling approaches to build an integrated protein atlas of the
human dividing
cell.