In
humans with pancreatitis, however, no benefit has been shown with plasma transfusion.
Not exact matches
Mentula P, Kylanpaa ML, Kemppainen E, Jansson SE, Sarna S, Puolakkainen P, Haapiainen R, Repo H.Plasma anti-infl ammatory cytokines and monocyte
human leucocyte antigen - DR expression in patients
with acute
pancreatitis.
Oral pancreatic enzyme extracts have been reported to reduce pain in
humans with chronic
pancreatitis, though this is controversial.
Consumption of plasma protease inhibitors and saturation of available α2 - macroglobulin by activated proteases is rapidly followed by acute disseminated intravascular coagulation, shock and death.34, 35 Although a clinical trial in
humans has failed to show the beneficial effects of fresh - frozen plasma directed at replenishing α2 - macroglobulin stores, there is anecdotal evidence of its benefit in dogs
with pancreatitis.36 Transfusion of fresh frozen plasma (10 - 20 ml / kg) to replace natural protease inhibitors such as α2 - macroglobulin is frequently associated
with amelioration of the deleterious effects associated
with inflammatory mediators and activated proteases.
(ref)
Humans with chronic bowel inflammation are four times as likely to develop
pancreatitis as well (ref)
A recent
human study showed an increased death rate for patients
with severe acute
pancreatitis when probiotics were administered, possibly due to reduced blood flow to the small intestine.
We also know that a small proportion of dogs (and
humans)
with chronic
pancreatitis will eventually destroy enough of their pancreas to develop EPI and / or diabetes.
VetFolio reports the routine use of antibiotics is considered to be of no benefit in animals
with pancreatitis because, in contrast to
human pancreatitis patients, bacteria do not seem to play a role in
pancreatitis in small animals.
Similar studies in
human patients
with pancreatitis have failed to document a benefit of FFP use.
However
human studies of those
with necrotising
pancreatitis have failed to conclusively prove a benefit to pursuing surgery over less invasive options (transcutaneous CT - guided drainage, endoscopic trans - enteric drainage).
Thus, the question arises whether dogs
with pancreatitis have abdominal pain less frequently than
humans, or more likely, whether we fail to correctly identify abdominal pain.
Since canine
pancreatitis has a lot of similarities to this condition in
humans, multiple studies (but not majority)
with people have been used to draw conclusions on
pancreatitis in dogs [6].