Sentences with phrase «humoral responses»

Some of these «precursor outcomes» (e.g., heightened vigilance and preparedness for threats; enhanced inflammatory and humoral responses to infectious microorganisms) appear to be aimed at protection from immediate dangers; they may reflect «adaptive trade - offs» that balance short - term survival advantages under harsh rearing conditions against disadvantages manifested later in development.

For example, previous studies reported that only 23 % of immune sera examined contained specific serum IgG antibodies against PFA0135w, suggesting that this protein does not normally elicit strong humoral responses [59].

Together these approaches allowed us to highlight the focus of humoral responses and hypothesise new modes of pathogen immune evasion.

Immunization with different Pf AMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits.

Working with Inovio Pharmaceuticals, Duke University, Emory University, University of Massachusetts and the National Institutes of Health, the group aims to build on the success of previous generations of DNA vaccines in order to induce strong cellular and humoral responses.

We will evaluate the immunogenicity of vaccine candidates (provided by user) administered by systemic, transdermal or mucosal routes and will monitor humoral responses and cellular responses.

«In a stressed intestinal environment,» the authors note, «retinoic acid, which was thought to lessen inflammation in the intestine, acted as an adjuvant that promoted rather than prevented inflammatory cellular and humoral responses to fed antigen.»

We will also develop mathematical models to predict humoral responses to vaccination.

T cells play a central role in regulating the cellular and humoral responses towards invading pathogens and malignant transformation.

In the so - called humoral response, B - cells begin to secrete specific antibody proteins, which latch onto and neutralize pathogens in tissue or blood.

(**) C. Hammer et al.: Amino Acid Variation in HLA Class II Proteins Is a Major Determinant of Humoral Response to Common Viruses.

UNISI will investigate whether the magnitude of antigen - specific cellular responses generated after priming can predict the secondary humoral response.

Th2 cytokines are involved in the humoral response, leading to the production ofIgE antibodies.

In that study, only 1 of 12 patients had an anti-Id specific humoral response.

It is only in those dogs that have no viral antibody that the vaccine will booster the immune system, both the cellular and humoral response to the virus.

It is only in those dogs that have no viral antibody that the vaccine will boost the immune system, both the cellular and humoral response to the virus.

Not exact matches

Jäger E, Karbach J, Gnjatic S, Neumann A, Bender A, Valmori D, Ayyoub M, Ritter E, Ritter G, Jäger D, Panicali D, Hoffman E, Pan L, Oettgen H, Old LJ, Knuth A. Recombinant vaccinia / fowlpox NY - ESO - 1 vaccines induce both humoral and cellular NY - ESO -1-specific immune responses in cancer patients.

Michael Pfreundschuh and colleagues Ugur Sahin and Ozlem Türeci at the University of Saarland develop SEREX (SErological analysis of Recombinant cDNA Expression), providing a powerful method to analyze the humoral immune response to intracellular cancer antigens and ushering in the third phase of cancer serology, bringing with it the prospect of providing a comprehensive view of the immune recognition of human cancer.

DC are the most influential APC, playing a key role in directing cellular and humoral immune responses against self and non-self antigens 110.

Jäger E, Stockert E, Zidianakis Z, Chen YT, Karbach J, Jäger D, Arand M, Ritter G, Old LJ, Knuth A. Humoral immune responses of cancer patients against «Cancer - Testis» antigen NY - ESO - 1: correlation with clinical events.

We produce live and inactivated viruses in our BSL2 and BSL3 facilities, and perform immunogenicity and efficacy studies in pigs (influenza) and sheep (RSV) with a focus on skin vaccination and extended monitoring of humoral and cellular immune responses in the blood and lung.

The late - boost study, led by scientists from AFRIMS and the Thai Ministry of Health, found that vaccine boosts containing AIDSVAX B / E generated increased, but short - lived, humoral and CD4 + T - cell responses that did not rise further after subsequent boosting.

The exact composition of germline V gene sequences in an individual has been difficult to determine due to the highly repetitive nature of the genomic sequences encoding these segments, thus limiting our understanding of humoral immune responses.

The CD4 subset is capable of directing B cell responses and humoral immunity, and can modulate the actions of many other cell types including CD8 T cells, dendritic cells, macrophages, eosinophils, and basophils.

BELLEROPHON aimed at developing a Staphylococcus aureus vaccine targeting cellular and humoral immune responses.

A Phase 1 study in malaria - naïve North American volunteers found that the AMA1 - based vaccine FMP2.1 / AS02A elicited potent humoral and cellular immune responses and that immune sera recognized sporozoites and merozoites by immunofluorescence assay and inhibited both parasite growth and AMA1 processing in homologous 3D7 parasites [16].

Dose Selection for an Adjuvanted Respiratory Syncytial Virus F Protein Vaccine for Older Adults Based on Humoral and Cellular Immune Responses.

The vaccine aims at inducing both a humoral and cellular immune response and it is covering all four dengue serotype E-proteins.

You will be responsible for the development of immune assays to facilitate the assessment of responses post nairovirus exposure, including assessment of both cellular and humoral immunity.

Although much is known regarding the specificity and efficacy of antibody responses, our knowledge of the function, phenotype, and specificity of the antigen - specific B cells that are responsible for antibody production, as well as for long - term humoral memory, is inadequate.

In Stiff Person Syndrome, which is a rare autoimmune disease in the central nervous system with autoantibodies targeting glutamic acid decarboxylase (GAD65), the humoral autoimmune response was shown to consist of a Rituximab - sensitive part rapidly cleared after treatment, and a Rituximab - resistant part from long - lived and persistent plasma cells acting as a reservoir for secretion of autoantibodies.

«Given separately and concurrently, both vaccines were safe, well - tolerated, and elicited antigen - specific humoral and cellular immune responses.»

We are currently investigating the role of various T - cell costimulatory pathways in regulating the humoral and cellular responses to and between DENV and ZIKV, and are defining the particular pathways that should be targeted to maximize safety and efficacy of vaccines.

Odunsi K, Qian F, Matsuzaki J, Mhawech - Fauceglia P, Andrews C, Hoffman EW, Pan L. Ritter G, Villella J, Thomas B, Rodabaugh K, Lele S, Shrikant P, Old LJ, Gnjatic S. (2007) Vaccination with an NY - ESO - 1 peptide of HLA class I / II specificities induces integrated humoral and T cell responses in ovarian cancer.

In 2010, we formally demonstrated ADE by developing a mouse mode of ADE - mediated disease, and we began to dissect the contribution of humoral vs. cellular immune components in dengue vaccine - mediated protection using model vaccine candidates as tools to probe the mechanisms by which the vaccine - induced immune responses in mice contribute to protection vs. ADE.

Immunogenicity and efficacy studies in pig (influenza) and sheep (RSV) with a focus on skin vaccination and extended monitoring of humoral and cellular immune responses in the blood and lung.

Multiple efforts are underway to characterize the humoral and cellular responses to vaccine candidates in our portfolio, including extensive systems - level analyses.

Our data indicate that 3 of 16 patients mounted a vaccine - specific humoral immune response.

Immune cells that play a large role in humoral immune response.

Production of these antibodies against the BBB and other neural cell antigens from a cell - mediated and humoral immune response may indicate a pathological alteration of the protective brain barrier.

In fact the presence of good humoral antibody levels blocks the anamnestic response to vaccine boosters just as maternal antibody blocks the response in some young animals.»

This allows the vaccine to mimic natural infection, while taking advantage of the cat's entire immune system and prompting a broad humoral and cell - mediated response.

Evaluation of the ability of canarypox - vectored equine influenza virus vaccines to induce humoral immune responses against canine influenza viruses in dogs.

Vitamin A and E have been shown to enhance immune function in small animals, as the former can beneficially influence T - helper responses, and the latter is known to improve both cellular and humoral immunity.

MetaStim, the common name for the SP (squalane, Pluronic ®) oil adjuvant, is an emulsion used in vaccines to help elicit a humoral and cell - mediated immune response.

Astaxanthin stimulates cell - mediated and humoral immune responses in cats.

For example, the dietary carotenoid astaxanthin stimulates cell - mediated and humoral immune responses in cats (Park et al. 2011) and dogs (Chew et al. 2011).

The development of CMI is the most crucial factor in determining the ultimate outcome of FIPV infection.4, 5,12 Cats that produce humoral antibodies but fail to generate an effective CMI response develop effusive FIP.4, 5 Experimental evidence demonstrates that cats with non-effusive FIP often have preceding, transient effusive disease.4 Thus, noneffusive FIP is believed to result from a partially protective CMI response that is unable to wall off and contain the virus.4

She returned to Glasgow Veterinary School to research into FIP, her PhD was entitled «Studies on the humoral immune response to feline coronavirus.»

This happens in dogs with insufficient cell mediated immunity and humoral immune response.