ENCODE has laid a foundation for these kinds of studies by examining more than 140 of
the hundreds of cell types found in the human body and identifying many of the cell type - specific control elements.
They are the only ones capable of generating any cell type from
the hundreds of cell types that make up an adult organism, so they are the first step towards curing illnesses such as Alzheimer, Parkinson's disease or diabetes.
Though a range of developmental scenarios in multiple brain regions is surely at work in ASDs, the researchers said the ability to place these specific genetic mutations in one specific set of cells — among
hundreds of cell types in the brain, and at a specific point in human development — is a critical step in beginning to understand how autism comes about.
Also amazing is the way the immune system distin - guishes between foreign sub - stances and
the hundreds of cell types that make up our body.
Not exact matches
Each
of us develops from an unspecialized single
cell into
hundreds of different specific
cell types.
The molecule miR - 182 is a microRNA, a
type of short non-coding RNA that can bind to
hundreds of genes to reduce their protein expression in
cells.
When a virus invades a
cell, one
of the body's first signals that it's under attack comes from
type I interferon proteins, which then rev up the production
of hundreds of proteins that fight the virus.
Using DNA strands just 58 nucleotides long to uniquely identify each particle allows researchers to skip the
cell culture screening altogether — and test a
hundred or more different
types of nanoparticles simultaneously in just a handful
of animals.
And that differentiation could provide a structural basis to help explain how
cells with the same overall genome nonetheless can differentiate into
hundreds of different
cell types.
They tried
hundreds of different recipes; eventually they discovered that if they mixed liver precursor
cells (derived from iPS
cells) with two other
types of standard human
cell lines known to be important for embryonic liver development, then the
cells would spontaneously form a 4 to 5 - millimeter 3D structure called a liver bud.
He adds, «This study was actually a pilot project for a much larger effort within the Center for Molecular Therapeutics to map responses against drug combinations across
hundreds of cancer
cell lines, not just melanoma, and look for novel combinations that will benefit subsets
of patients regardless
of the particular
type of tumor they have.
In the study, researchers exposed a handful
of mouse and human T -
cell receptors to
hundreds of millions
of peptides, and found
hundreds of peptides that bound to each
type.
«If you went back a few years and opened a textbook you'd see the classic hippocampal circuit that's been diagrammed for a
hundred years, and you'd look at the subiculum and you'd see it labeled as one region, with one
type of cell, doing one thing,» Cembrowski explains.
This effort will combine deep knowledge
of immunological lineages, clinical expertise and infrastructure needed to procure and process diverse samples, genomic and computational expertise to resolve the
hundreds of finely differentiated
cell -
types that compose all facets
of the immune system, and the genomic signatures that define them.
Caribou Biosciences has generated
hundreds of thousands
of data points from engineering many thousands
of genomic sites across several different
cell types.
Using machine learning technology, the researchers analyzed
hundreds of existing datasets from six different
cell types to look for patterns in the genome that identify where a gene and enhancer interact.
Kriegstein said the identification
of hundreds of novel biomarkers for diverse
cell types will improve scientists» understanding
of the emergence
of specialized neuronal subtypes.
«We have identified novel molecular features in diverse
cell types using a new strategy of analyzing hundreds of cells individually,» said Arnold Kriegstein, MD, PhD, director of the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at U
cell types using a new strategy
of analyzing
hundreds of cells individually,» said Arnold Kriegstein, MD, PhD, director
of the Eli and Edythe Broad Center
of Regeneration Medicine and Stem
Cell Research at U
Cell Research at UCSF.
The grand architecture
of the human cortex, with its
hundreds of distinct
cell types, begins as a uniform layer
of neural stem
cells and builds itself from the inside out during several months
of embryonic development.
Our bodies are comprised
of several
hundred different
cell types, yet each
cell possesses the same genetic material.
The current project iteration, FANTOM5, has mapped enhancers and transcription start sites in
hundreds of primary human
cell types.
There are companies that specialise in making
cell lines
of certain genotypes that are sold for
hundreds of dollars, and different
cell types need different growth media and additives in order to grow.
Among these achievements are the development
of new techniques for classifying different
types of neurons; automated methods for creating wiring diagrams
of the connections between
cells in the mammalian brain; new ways
of recording and manipulating the electrical activity
of hundreds, even thousands,
of cells simultaneously; and, advanced microscopes that allow researchers to visualize the activity
of all the
cells in the brains
of small animals.
This
type of dieting has been put to the test
hundreds of times and has been shown repeatedly to decrease insulin levels, which in turn helps with weight loss; increase the amount
of HGH (Human Growth Hormone) and even repair
cells and help with their recovery.
Ultimately, what the immune system produces is several
hundred various
types of antibodies and excrete immune boosting interleukins and cytokines on top
of what it normally produces with the whole
cell on its own.
It involves dozens
of cell types and
hundreds of different signalling molecules, all
of which communicate in immensely complex ways.
«We hope to educate
hundreds of veterinarians in Colorado about stem
cell therapy, and offer them local expertise and clinical support for difficult cases through this unique
type of partnership with a state
of the art veterinary practice.
Cancer is a general term that encompasses over a
hundred disease -
types, involving the growth
of abnormal
cells.
Slip your feet into cool water and relax while
hundreds of garra rufa, a
type of carp that ranges in size from one to two - and - a-half inches, literally sucks the dead skin
cells from your feet.