Sentences with phrase «huntingtin aggregates»
Mochly - Rosen and colleagues identified several other potential biomarkers that were elevated in HD model mice, including the levels of 8 - hydroxy - deoxy - guanosine, a product of oxidative DNA damage, in the urine and the presence of mutant huntingtin aggregates and oxidative damage in muscle and skin cells.
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«We already know from previous studies on the protein huntingtin, which spontaneously forms aggregates and is responsible for the development of the neurodegenerative disorder Huntington's disease, that protein aggregates also bind to essential proteins that have no defects.»
The team's ongoing study is now looking at how the complete huntingtin protein, which contains parts in addition to the polyglutamine repeats, aggregates.
The mutant Huntingtin gene is thought to cause toxic levels of protein to aggregate in the brain.
The Max Planck scientists could also show that a toxic protein related to the abnormal, aggregate - forming protein «huntingtin» of patients with the neurodegenerative Huntington's disease is efficiently destroyed by the newly identified pathway.