Sentences with phrase «huntingtin during»
Nonetheless, the Dragatsis team used this method to try and understand the extreme case of loss of huntingtin during adulthood.
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The huntingtin (htt) protein has been found to play an essential role during embryogenesis, since knockout Hdh mice do not survive gestation (Duyao et al., 1995; Nasir et al., 1995; Zeitlin et al., 1995).
The edits made to the Huntingtin gene during the first four weeks will remain forever, but the eventual deactivation of the Cas nuclease reduces the chances of harmful effects later on.
During translation, however, the RNA instructions for extra-long huntingtin can also interact with a helper complex (the assistant chef from our analogy).
To study what happens when huntingtin is removed during adulthood, a team of researchers led by Ioannis Dragatsis at the University of Tennessee used a genetic tool to precisely time the removal of huntingtin in a large proportion of cells all over the body.
This led scientists to deduce that normal huntingtin is very important during development, especially in the brain.