Sentences with phrase «huntingtin over»
And when they tracked the striatal neurons carrying the mutant huntingtin over time, they found them much more likely to die than those from other brain regions.
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When the huntingtin gene is deleted at an age older than four months, these mice appeared to stay healthy, despite having lost their huntingtin genes in cells all over their bodies.
Buck researchers established an unprecedented large - scale interaction network for the huntingtin protein identifying 2,141 highly interconnected proteins that have over 3,200 interactions among them.
Clumps of mutant huntingtin protein in brain cells are a hallmark of HD, and they build up slowly, occupying more and more cells over time.
In this study, we employed a method called optical pulse - labeling, or OPL, which allowed us to see how the mutant huntingtin ravaged the brain over time — neuron by neuron.»
In HD, a repeated sequence of letters in this gene leads to an extra-long form of huntingtin protein that can wreak havoc in brain cells over long periods of time.
To study what happens when huntingtin is removed during adulthood, a team of researchers led by Ioannis Dragatsis at the University of Tennessee used a genetic tool to precisely time the removal of huntingtin in a large proportion of cells all over the body.