Sentences with phrase «hydrazine hydrochloride»

The synthesis of J147 has been carried out using simple chemistry as described in our previous paper by condensation of 3 - methoxybenzaldehyde and (2, 4 - dimethylphenyl) hydrazine hydrochloride in EtOH at room temperature, followed by acetylation using trifluoroacetic anhydride and triethylamine in CH2Cl2 gave J147 (Scheme 1).

A mixture of 3 - methoxybenzaldehyde (50 g, 367.64 mmol) and (2, 4 - dimethylphenyl) hydrazine hydrochloride (63.23 g, 367.64 mmol) in EtOH (50 mL) was stirred at room temperature for 1 h, the obtained solid was filtered off, washed with ethanol and dried under vacuum to afford hydrazone hydrochloride 1 (95.94 g) in 90 % yield as a light brown solid.