The study was based on approximately 80,000 skin cancer cases and revealed that skin cancer risk is as much as seven times greater for people
using hydrochlorothiazide containing blood pressure medication.
This study established a clear association
between hydrochlorothiazide containing hypertension medication and an increased chance of developing squamous cell carcinoma.
They include feeding you cat only canned, frozen or home - cooked diets, moderately increasing the amount of salt in your cat's diet, and, in carefully chosen cases, administering diuretic medications
like hydrochlorothiazide.
Even though we knew that
hydrochlorothiazide made you sensitive to the sun, the connection between this medicine and skin cancer has remained elusive.
The combination of living and residing in sunny Florida while
taking hydrochlorothiazide seems to be very serious and even life - threatening for some patients.
It had already been established that
hydrochlorothiazide caused the skin to become more vulnerable to UV ray damage, but it was previously unknown that long - term usage of this hypertension medication resulted in such a large increase in skin cancer risk.
However, if you use
hydrochlorothiazide at present, it may be a good idea to talk to your doctor to see if it is possible to choose a different medicine,» says Anton Pottegård.
This means that
hydrochlorothiazide enhances the harmful effects of sunlight in the skin and lips, and this can increase the risk of skin cancer.
The side effects can therefore affect numerous people, and the researchers have calculated that about 10 percent of all Danish cases of squamous cell carcinoma may be caused
by hydrochlorothiazide.
There are many different types of diuretics including loop diuretics such as furosemide (Lasix ®), thiazide diuretics such
as hydrochlorothiazide (Microzide ®), and potassium - sparing diuretics such as spironolactone (Aldactone ®).
But I would certainly add a moderate amount before I would resort to
hydrochlorothiazide diuretic treatment when I could not keep my pet's urine specific gravity low without it.
Use acetazolamide with caution when administering the following drugs: primidone, phenytoin, quinidine, procainamide, phenobarbital, methotrexate, methenamine, corticosteroids (e.g. prednisone, dexamethasone), amphotericin B and other diuretics (
e.g. hydrochlorothiazide).
«We knew that
hydrochlorothiazide made the skin more vulnerable to damage from the sun's UV rays, but what is new and also surprising is that long - term use of this blood pressure medicine leads to such a significant increase in the risk of skin cancer,» says Anton Pottegård, Associate Professor, PhD, from the University of Southern Denmark, who is the initiator of the study.
The study, which is based on about 80,000 Danish cases of skin cancer, shows that the risk of developing skin cancer is up to seven times greater for users of medicine
containing hydrochlorothiazide.
Certain other drugs contain «hydrochlor,» which is not chemically related to
hydrochlorothiazide and does not increase the risk of skin cancer.
When
hydrochlorothiazide induces cancer, this is because hydrochlorothiazide belongs to a group of drugs with a so - called photosensitising effect.
The risk of skin cancer increases the more
hydrochlorothiazide you have taken throughout your lifetime, and the risk of squamous cell carcinoma was up to seven times greater for people who had taken hydrochlorothiazide in an amount corresponding to > 10 years» use.
The researchers continue to work on studies that can shed additional light on the connection between
hydrochlorothiazide and skin cancer.
«We have seen and followed many patients with different skin cancers where the only risk factor apart from exposure to sunlight seems to be
hydrochlorothiazide.
Dr. Cognetta has extensive experience in diagnosing and treating skin cancer patients in Florida, and he has noted that
hydrochlorothiazide is suspiciously prevalent among his patients, particularly among so - called «catastrophic patients,» who can have several hundred skin cancers each.
«The risk of skin cancer must, of course, be weighed against the fact that
hydrochlorothiazide is an effective and otherwise safe treatment for most patients.
More specifically, this refers to drugs containing
hydrochlorothiazide and squamous cell carcinoma.
Once again, Danish researchers set their sights on antihypertensive medicine containing
hydrochlorothiazide, in relation to an increased risk for skin cancer.
On the roster:
hydrochlorothiazide, atorvastatin, amlodipine, simvastatin and others.
Other medications containing «hydrochlor», which isn't chemically related to
hydrochlorothiazide, do not increase skin cancer risk.
The more
hydrochlorothiazide that's been used throughout a lifetime, the greater the risk of skin cancer, with the risk of squamous cell carcinoma as much as seven times greater for people who had been using hydrochlorothiazide in an amount that corresponded to 10 years» or more of usage.
Thiazide diuretics such as chlorthalidone (Hygroton ®) and
hydrochlorothiazide (Esidrix ® and HydroDIURIL ®) increase urinary zinc excretion by as much as 60 % [88].
Top - selling blood - pressure medications include lisinopril (Prinivil, Zestril), an ACE inhibitor; amlodipine (Norvasc), a calcium channel blocker;
hydrochlorothiazide (HCTZ and various other brand names), a thiazide diuretic; furosemide (Lasix), a loop diuretic; and metoprolol (Lopressor, Toprol), a beta blocker.
Lasix,
hydrochlorothiazide)
There are three major categories of diuretics: thiazide diuretics (
hydrochlorothiazide), loop diuretics (Furosemide), and potassium sparing diuretics (Spironolactone).
If your pet is allergic to sulfa antibiotics, the diuretic Furosemide or
hydrochlorothiazide should not be used.
The most common one used for this purpose is
hydrochlorothiazide.
Chlorothiazide and
hydrochlorothiazide are diuretics.
They include feeding you dog only canned, frozen or home - cooked diets, moderately increasing the amount of salt in your dog's diet, and, in carefully chosen cases, administering diuretic medications like
hydrochlorothiazide.