Sentences with phrase «hydrogels by»

The researchers made the hydrogels by mixing together microbeads of one type of hydrogel that degrades very rapidly in a solution of another polymer that degrades much more slowly.

«In our research, we were able to create an entirely recombinant protein - based light - sensitive hydrogels by covalently assembling the CarHC photoreceptor proteins using genetically encoded SpyTag - SpyCatcher chemistry,» said Fei Sun, author of the paper and assistant professor at HKUST's department of chemical and biomolecular engineering.

The idea is that the drug, being within the nano - hydrogels, is transported directly to cancer cells where it can be released without damaging other parts of the body, because hydrogels offer the possibility of dosing a myriad of active substances on the site desired and can be administered as dry or swollen hydrogels by different routes: oral, nasal, buccal, rectal, transdermal, vaginal, ocular and parental.

Not exact matches

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«Protein Cross-linked Hydrogels» by Aaron Esser - Kahn Pros: Excellent editing.

The research team, led by bioengineering professor Adam Engler, also found that a protein binding the stem cell to the hydrogel is not a factor in the differentiation of the stem cell as previously suggested.

Engler's team, which includes bioengineering graduate student researchers Ludovic Vincent and Jessica Wen, found that the stem cell differentiation is a response to the mechanical deformation of the hydrogel from the force exerted by the cell.

For example, researchers are developing «smart» biomaterials such as temperature - sensing hydrogels that can respond biologically to environmental conditions by changing their biomechanical or drug - releasing properties, says Seeram Ramakrishna, a professor of mechanical engineering and director of the Center for Nanofibers & Nanotechnology at the National University of Singapore.

By creating fibrous hydrogels with different levels of crosslinks, the team was able to show that cells surrounded by matrices with fewer crosslinks were better able to draw in fibers and increase the number of focal adhesions around theBy creating fibrous hydrogels with different levels of crosslinks, the team was able to show that cells surrounded by matrices with fewer crosslinks were better able to draw in fibers and increase the number of focal adhesions around theby matrices with fewer crosslinks were better able to draw in fibers and increase the number of focal adhesions around them.

The micro-robot, which is remotely controlled by magnetic fields, can move one hydrogel at a time to build structures.

He and his colleagues began by designing a hydrogel, a network of polymers that absorbs large amounts of water.

As expected, the hydrogel material disappeared and was replaced by new tissue which grew around the islets.

Specifically, I am investigating how the cAMP / PKA signaling pathway affects collagen structure and deposition, using a hydrogel - based, three - dimensional culture system to create a model that is more physiologically relevant than one produced by standard two - dimensional tissue culture methods.

Inspired by the electric eel's ability to generate hundreds of volts, Guha and his colleagues stacked hydrogels full of varying strengths of salt water.

In an effort to create a power source for future implantable technologies, a team led by Michael Mayer from the University of Fribourg, along with researchers from the University of Michigan and UC San Diego, developed an electric eel - inspired device that produced 110 volts from gels filled with water, called hydrogels.

This elastic hydrogel is formed by using a light - activated polypeptide.

«When the interlocked arrays are exposed to water, a notable volume expansion of a corresponding shape transformation of the hydrogel microhooks occurred by the swelling of the hydrogel, resulting in significantly increased wet adhesion both in the shear and normal directions.»

This hydrogel patent, along with several other patent pending applications, are licensed by the startup company PepGel LLC, which was co-founded by Sun and Huang to make their technology available for research use and medical device applications.

The team reports that ELP hydrogel can be digested overtime by naturally - occurring enzymes and does not appear to have toxic effects when tested with living cells in the lab.

In addition to being able to rapidly change forms, the hydrogel formulas created by Sun and Huang are resistant to high temperatures up to 80 - degrees Celsius at a neutral pH level.

The team also found that they could control how much the material swelled as well its strength, finding that the ELP hydrogel could withstand more stretching than experienced by arterial tissue in the body.

The researchers modified the HA molecules by attaching adamantane and cyclodextrin groups to allow the gels to flow through catheters, and they added thiol and methacrylate groups to enable post-injection cross-linking to stiffen the hydrogel.

But his team has gone a step further by identifying properties that would be useful in treating heart attack patients and then designing hydrogels with those properties.

«The hydrogel is designed so that drug release is triggered by the activity of specific, arthritis - related enzymes that are increased during flares.

The synthetic hydrogel had disappeared, replaced by natural extracellular matrix produced by the cells themselves.

Stroock created the same tension in his transpiring system by using a high - tech fabric of cross-linked polymers called a hydrogel.

Moradian - Oldak will couple the MMP - 20 discovery with another study published Nov. 2 in the Journal of Biomedical Engineering and Informatics, which concluded an amelogenin - chitosan hydrogel could repair early tooth decay by growing an enamel - like layer that reduces lesions by up to 70 percent.

The nano - hydrogels have shown very good characteristics of biocompatibility with the human organism, due to their physical properties, which make them resemble living tissues, especially by its high water content, its soft and elastic consistency, and its low interfacial tension which prevents them from absorbing proteins from body fluids.

By combining emulsion polymerization and microemulsion the were able to synthesize structured hydrogels which present degrees of swelling and have better mechanical properties than conventional hydrogels, said the researcher.

By adding water to the chamber, the crystals activate and cool the hydrogel to operating temperatures within 30 seconds.

«Since the initial hydrogel's transition temperature was very close to the temperature of the human eye, we had to modify its properties to ensure that it would form a solid seal as soon as the gel was applied to the eye by a soldier or medic,» says lead author Niki Bayat, a doctoral candidate in the Mork Family Department of Chemical Engineering and Materials Science at the USC Viterbi School.

«First responders at a mass casualty incident could deploy the hydrogel while patients wait for their injuries to be completely repaired by an ocular surgeon in appropriate microsurgical facilities,» he says.

When an ophthalmologist is ready to repair the eye, the hydrogel can be extracted by applying cool water and converting it back to a less adhesive state.

Mooney and his team decided to mimic the viscoelasticity of living tissue by developing hydrogels with different stress relaxation responses.

By introducing different degradable groups to the polymer chains, the researchers were able to alter how long it took for the hydrogels to degrade.

In pre-clinical studies conducted by the researchers, a one - time, local injection of the hydrogel - drug combo prevented graft rejection for more than 100 days compared to 35.5 days for recipients receiving only tacrolimus and 11 days for recipients without treatment or only receiving hydrogel.

Other researchers have created such gels by engineering proteins that self - assemble into hydrogels, but this approach requires complex biochemical processes.

Benoit and her team were able to manipulate the time it took for hydrogels to dissolve by modifying groups of atoms — called degradable groups — within the polymer molecules.

After the filaments are injected into the body, the resulting hydrogel network functions as a drug depot that slowly degrades by breaking down into spherical nanomaterials called micelles, which are programmed to travel to specific targets.

By integrating the nanosponges into a hydrogel, we can retain them at the site of infection.»

To make the nanosponge - hydrogel, the team mixed nanosponges, which are nanoparticles that absorb dangerous toxins produced by MRSA, E. coli and other antibiotic - resistant bacteria, into a hydrogel, which is a gel made of water and polymers.

«The AdoB12 - dependent CarHC tetramerization has been shown to be essential for the formation of an elastic hydrogel in the dark, which can undergo a rapid gel - sol transition caused by light - induced CarHC disassembly.»

Ting Liu at the Chinese Academy of Sciences in Beijing and her colleagues built the nanogenerator by sandwiching a layer of hydrogel between a stretchy plastic material called an elastomer, then coating it in silicone rubber to keep the hydrogel from drying out.

«After injecting the nanosponge - hydrogel at the infected spot, we observed that it absorbed the toxins secreted by the bacteria and prevented further damage to the local blood, skin and muscle tissues,» said Zhang.

A component in that protein, DOPA (for 3,4 - dihydroxyphenylalanine), has unusual properties shared by its chemical cousin, dopamine, and it was dopamine that Lee incorporated into their hydrogel.

The unique property of the hydrogel developed by the RIKEN team is that it acts like an artificial muscle, which does not contract equally in all directions.

This new method of mobility expands the hydrogel's use as an environmental and biotechnological tool by allowing them to explore new areas such as surface waters to combat toxic elements, or cavities inside the human body.»

A hydrogel could be programmed to adopt all manner of shapes by changing the placement of the ions, the composition of the hydrogel and the voltage.

Using a method that they published earlier this year, the team arranged metal - oxide nanosheets into a single plane within a material by using a magnetic field and then fixed them in place using a procedure called light - triggered in - situ vinyl polymerization, which essentially uses light to congeal a substance into a hydrogel.