Sentences with word «hydrolase»
A hydrolase is an enzyme that helps break down molecules by using water. It facilitates a chemical reaction called hydrolysis, where water molecules split apart larger molecules into smaller ones. Full definition
The problem was an enzyme called soluble epoxide hydrolase (sEH), which breaks down and inactivates EDP.
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Structural and biochemical characterization of novel bacterial α - galactosidases belonging to glycoside hydrolase family 31
«Biosensing paraoxon in simulated environmental samples by immobilized organophosphorus hydrolase in functionalized mesoporous silica.»
Reykjavik, ICELAND, January 9, 2008 — deCODE genetics (Nasdaq: DCGN) today announced positive topline results from its Phase IIa clinical trial for DG051, the company's leukotriene A4 hydrolase inhibitor being developed for the prevention of heart attack.
A new study exploring the NUDIX hydrolases in human cells provides attractive opportunities for expanding the use of this enzyme family as biomarkers and potential novel drug targets.
The study, supported by the British Heart Foundation, used mice to investigate the process by which these nitro fatty acids lower blood pressure, looking at whether they inhibited an enzyme known as soluble Epoxide Hydrolase which regulates blood pressure.
This protein, bile salt hydrolase, is commonly made by gut bacteria and functions to change the chemical properties of bile acids in the gut.
Identification of oxidized protein hydrolase as a potential prodrug target in prostate cancer.
Through collaborations with i.a. the SciLifeLab Biochemical and Cellular Screening facility, members of the Human Protein Atlas and teams supervised by Carolina Wählby (Uppsala University / SciLifeLab), Erik Sonnhammer (Stockholm University / SciLifeLab), and Pål Stenmark (Stockholm University), a comprehensive overview of the human NUDIX hydrolases has been produced.
deCODE genetics (Nasdaq: DCGN) today announced that it has begun enrolling patients for its Phase IIa clinical trial for DG051, the company's leukotriene A4 hydrolase inhibitor being developed for the prevention of heart attack.
One of the most potent compounds, WWL113, turned out to work principally by inhibiting Ces3, a serine hydrolase enzyme that scientists have not studied in the context of obesity or diabetes.
Publishing online in Science, the researchers report that the molecule to which progesterone must bind is the enzyme alpha / beta hydrolase domain containing protein 2 (ABHD2), found in the sperm cell's outer membrane.
We show that oxidative modifications of ubiquitin carboxyl - terminal hydrolase L1 (UCH - L1), γ - enolase, actin, and dimethylarginine dimethylaminohydrolase 1 (DMDMAH - 1) are present in the brain of familial AD
We show that oxidative modifications of ubiquitin carboxyl - terminal hydrolase L1 (UCH - L1), γ - enolase, actin, and dimethylarginine dimethylaminohydrolase 1 (DMDMAH - 1) are present in the brain of familial AD... subjects.
The study, which appears as a Nature Chemical Biology Advance Online Publication on March 28, 2016, began as an effort in the Cravatt laboratory to discover and characterize new serine / threonine hydrolases using fluorophosphonate (FP) probes — molecules that selectively bind and, in effect, label the active sites of these enzymes.
Structures of a bifunctional cell wall hydrolase CwlT containing a novel bacterial lysozyme and an NlpC / P60 DL - endopeptidase.
In noncarnivorous plants, jasmonic acid triggers the synthesis of self - defense toxins and molecules that inhibit hydrolases, enzymes that herbivores secrete to break down the plant's proteins.
BIA 10 - 2474 inhibits an enzyme called fatty acid amide hydrolase (FAAH), which breaks down endocannabinoids in the brain.
As part of their counterattack, plants also produce their own hydrolases, which can destroy chitin and other components of insects or microbes.
In the flytrap, in contrast, jasmonic acid triggers a voracious response: Tens of thousands of tiny glands make and secrete hydrolases.
Population dynamics of library clones revealed Bt genes conferring significant fitness advantages in E. coli over time, including carbohydrate utilization genes, with a Bt galactokinase central to early colonization, and subsequent dominance by a Bt glycoside hydrolase enabling sucrose metabolism coupled with co ‐ evolution of the plasmid library and E. coli genome driving increased galactose utilization.
Protease and Hydrolase Subcommittee Drug Target and Chemistry Curation Subcommittee (Chair) Ex Officio (Senior Cheminformatician / Curator) Data Interoperability Subcommittee
Adjunctive dexamethasone for the treatment of HIV - uninfected adults with tuberculous meningitis stratified by Leukotriene A4 hydrolase genotype (LAST ACT): Study protocol for a randomised double blind placebo controlled non-inferiority trial
The team of scientists nevertheless identified them as «outlier» members of the serine / threonine hydrolase class, using newer techniques that detect biochemical activity.
Pulling FP - binding proteins out of the entire proteome of test cells and identifying them using mass spectrometry techniques, the team matched nearly all to known hydrolases.
Furthermore supraphysiological levels of many acidic hydrolases have no deleterious effect.
Monroe, J.D., A.R. Storm, E.M. Badley, M.D. Lehman, S.M. Platt, L.K. Saunders, J.M. Schmitz, and C.E. Torres (2014) β - amylase1 and β - amylase3 are plastidic starch hydrolases in Arabidopsis that appear to be adapted for different thermal, pH, and stress conditions.
In this assay SAHH (S - adenosylhomocysteine hydrolase) and adenosine deaminase convert the methyltransferase reaction product (S - adenosylhomocysteine) to homocysteine and inosine.
The fumarylacetoacetate hydrolase (FAH) superfamily of enzymes: multifunctional enzymes from microbes to mitochondria
Characterization of a tobacco epoxide hydrolase gene induced during the resistance response to TMV
Chia - Shan Wu, Daniel Morgan, Chris P. Jew, Chris Haskins, Mary - Jeanette Andrews, Corinne M. Spencer, Traci Czyzyk, Heather Bradshaw, Ken Mackie, Hui - Chen Lu (2014) «Long - term consequences of perinatal fatty acid amino hydrolase inhibition», British J. Pharmacology, 171:1420 - 34.
Galactomannase, also known as gammanase hydrolases, break down galactomannans.
Hauri HP, Sterchi EE, Bienz D, Fransen JA, Marxer A. Expression and intracellular transport of microvillus membrane hydrolases inhuman intestinal epithelial cells.
Bacterial UDP - Glucose Hydrolases and P2 Receptor - Mediated Responses to Infection: A Commentary
The researchers mixed RHP with a protein called organophosphorus hydrolase (OPH), which degrades the toxic organophosphates found in insecticides and chemical warfare agents.
A combination of genomic (available here, here, here and here) and proteomic analyses indicated a glycoside hydrolase family 12 protein was critical in the high activity of one consortium.
Thus, the study concludes that the protective effect of the Mediterranean diet, combining unsaturated fats and vegetables abundant in nitrite and nitrate, comes at least in part from the nitro fatty acids generated which inhibit soluble Epoxide Hydrolase to lower blood pressure.
Bile salt hydrolase - mediated inhibitory effect of Bacteroides ovatus on growth of Clostridium difficile — Soobin Yoon — Journal of Microbiology
Crystal structure of an alpha / beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution.
The researchers have shown the enzyme called soluble epoxide hydrolase (sEH) to be capable of reducing the symptoms of diabetes in mice by stabilizing metabolites in an omega - 3 acid called DHA.
Structure - and context - based analysis of the GxGYxYP family reveals a new putative class of Glycoside Hydrolase.
It turns out SOBER1 can be classified as part of a vast protein superfamily known as alpha / beta hydrolases.