Using lipid nanotubes as substrates to directly measure geometric intermediates of the fission pathway, we found that GTP
hydrolysis limits dynamin polymerization into short, metastable collars that are optimal for fission.
«Not only is our physics - based simulation and animation system as good as other data - based modeling systems, it led to the new scientific insight that the
limited motion of the dynein hinge focuses the energy released by ATP
hydrolysis, which causes dynein's shape change and drives microtubule sliding and axoneme motion,» says Ingber.