Sentences with word «hydroxychloroquine»

A phase I / II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme.

Whereas, a phase I / II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme led to no significant improvement in overall survival, which could be due to inconsistent autophagy inhibition in patients treated with this regimen [29].

Doctors have used hydroxychloroquine as an off - label alternative.

It is also given in conjunction with methotrexate and hydroxychloroquine as part of a regimen of «triple therapy» which has been shown to provide benefits to patients who have had inadequate responses to methotrexate alone.

It is not clear how often doctors use hydroxychloroquine off - label although it is believed to be a common practice.

In the largest group of results to date, researchers from Penn Medicine's Abramson Cancer Center and other institutions have shown in clinical trials that the malaria drug hydroxychloroquine (HCQ) blocked autophagy in a host of aggressive cancers — glioblastoma, melanoma, lymphoma and myeloma, renal and colon cancers — and in some cases helped stabilize disease.

Take for example the anti-parasitic medication hydroxychloroquine (with graph courtesy of Rx Savings Solutions).

It contains hydroxychloroquine (HCQ) which is disseminated slowly through the porous material of the tube and absorbed by the walls of the vaginal tract.

The study shows there was no benefit in taking hydroxychloroquine to control debilitating pain when compared to a placebo (dummy substance).

Lead researcher Dr Sarah Kingsbury, from the University of Leeds and NIHR Leeds Biomedical Research Centre at Chapel Allerton Hospital, said: «There is some scientific basis as to why hydroxychloroquine could be an effective drug agent.

Dr Kingsbury said: «Our findings do not support the current medical practice of giving hydroxychloroquine to patients with hand osteoarthritis.»

«But until now, there has not been a large - scale study into whether using hydroxychloroquine works.

«Doxycycline and hydroxychloroquine treatment exhibited a reproducible effect on the community structure of the gastrointestinal microbiota, with treated patients presenting significantly lower concentrations of beneficial bacteria, Bacteroidetes, Firmicutes, and Lactobacilli,» says coauthor Angelakis Emmanouil, of Unite de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), CNRS, Marseille.

The study, led by Didier Raoult, of Aix - Marseille University, Marseille, France, followed 48 patients who were being treated long - term with doxycycline and hydroxychloroquine for Q fever, and 34 control subjects.

The arms hold it in place while hydroxychloroquine, a malaria medication also shown to calm immune activation, is delivered and slowly absorbed by the walls of the vaginal tract.

Warhurst DC, Steele JC, Adagu IS, Craig JC, Cullander C. Hydroxychloroquine is much less active than chloroquine against chloroquine - resistant Plasmodium falciparum, in agreement with its physicochemical properties.

Ben - Zvi I, Kivity S, Langevitz P, Shoenfeld Y. Hydroxychloroquine: from malaria to autoimmunity.

Recently, chloroquines and hydroxychloroquines anti-malarial drugs have been identified by computational methods as promising inhibitors of the binding of SDF1 - α to CXCR4 and thus, potential agents for certain forms of cancer [103 - 106].

In preclinical trials, the effect of chloroquine and hydroxychloroquine on tumorigenesis has been extensively investigated in mouse cancer models, including genetic and xenograft models (summarized in Table 2).

So doctors have used hydroxychloroquine off - label, in a way that it was not licensed for, to try and control symptoms and pain.

Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors.

Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed / refractory myeloma.

The trial found that triple therapy, a combination of the inexpensive drugs sulfasalazine, hydroxychloroquine, and methotrexate is as effective as switching directly to biologics.

The first group was given the antibiotic doxycycline for 12 weeks, the second group was given a combination of the antibiotics clarithromycin and hydroxychloroquine, and the third group was given a placebo.

Hydroxychloroquine is an antimalarial drug that is also used to treat rheumatoid arthritis and lupus erythematosus.

«It is likely that physicians add either sulfasalazine or hydroxychloroquine one at a time to see if each drug works and is tolerated before adding the next drug.

Triple therapy for RA includes methotrexate, sulfasalazine and hydroxychloroquine.

In order to identify the binding sites of these derivatives, chloroquine 214 and hydroxychloroquine 215 were docked onto to the crystal structure of CXCR4.

Further studies have focused on the anti-neoplastic effects of chloroquine and hydroxychloroquine in the treatment of colon and pancreatic cancers although their mechanisms of action maybe due to their effects on multiple pathways [107 - 109].

Distinct non-cancer drugs already investigated in clinical cancer trials comprise metformin, aspirin, hydroxychloroquine and thalidomide [3, 4].

The inspection of several databases led to the identification of structural similarity between such lead and numerous quinoline or acridine derivatives, such as chloroquine, hydroxychloroquine and quinacrine.

Hydroxychloroquine is an antimalarial drug which is relatively safe and well - tolerated agent for the treatment of rheumatoid arthritis.

Hydroxychloroquine is sometimes combined with methotrexate for additive benefits for signs and symptoms or as part of a regimen of «triple therapy» with methotrexate and sulfasalazine.

Hydroxychloroquine / chloroquine inhibits autophagy by entering the lysosomes (lysosomotropic) and changing the acidity through chelating protons.

The drug is called Plaquenil (hydroxychloroquine), explained one expert who wasn't connected to the new study.

For mild cases, ibuprofen and naproxen can reduce pain and swelling in joints and muscles, and antimalarial drugs like Plaquenil (generic: hydroxychloroquine) have proven useful in preventing flares and controlling the diseases progression.

The most commonly prescribed antimalarial drugs for lupus are hydroxychloroquine (Plaquenil) and chloroquine (Aralen).

If progressive inflammation and joint destruction occurs despite NSAIDs treatment, more potent medications such as methotrexate, corticosteroids, and antimalarial medications (such as hydroxychloroquine, or Plaquenil) are used.

For those that do, it's usually a prescription for prednisone, methotrexate, or hydroxychloroquine.