The external layer, called the cuticle, does not contain polyphenols and is mainly made up of
hydroxyl fatty acids, while the layer closest to the pulp is where the majority of phenols are founds in the skin.
High PI and DBI equals short lifespan MLSP despite mitochondrial Glutathione and Thioredoxin trying its best to scavenge membrane Hydroperoxides formation from
hydroxyl radical stealing hydrogen atom from unsaturated
fatty acids (initiating lipid peroxidation propagation forming highly mutational reactive aldehydes (MDA, MDA - TBARS), alkenals (4 - HNE), methylglyoxals (creating glucosepane, MDA - Lys, CML, pentosidine, CEL, furosine from Amadori).