Sentences with word «hydroxylase»

Conversely, deletion of tyrosine hydroxylase in myeloid cells protects mice from the disease.

Soulafa Mamlouk (Breier, TUD)-- «Modulation of Prolyl Hydroxylase Domain 2 (PHD2) in Tumor Inflammation» (2012)

Savelieva, K.V.; Zhao, S.; Pogorelov, V.M.; Rajan, I.; Yang, Q.; Cullinan, E.; Lanthorn, T.H. Genetic disruption of both tryptophan hydroxylase genes strongly reduces serotonin in the brain and affects behavior in models sensitive to antidepressants.

Next the procollagen is catalysed with two hydroxylase enzymes which react with proline and also lysine.

The role of reversible phosphorylation in the hormonal control of phenylalanine hydroxylase in isolated rat proximal kidney tubules

An example is the so - called 21 - hydroxylase deficiency, the most frequent form of the congenital syndrome there the adrenal glands produce excess androgens, which are male hormones.

Nonclassical 21 - Hydroxylase Deficiency by Maria I. New MD.The Journal of Clinical Endocrinology & Metabolism Vol.

Eat broccoli, for instance, and the vitamin B6 it contains will spur the tryptophan hydroxylase gene to produce L - tryptophan, an amino acid used in the synthesis of serotonin, a neurochemical mood stabilizer.

Soy has been shown to affect tyrosine hydroxylase activity in animals, causing the utilization rate of dopamine to be «profoundly disturbed.»

He did a post-doc in the lab of Professor Chris Schofield working on the Hypoxia - inducible - factor hydroxylase Factor - Inhibiting - HIF and enzymes involved in biosynthesis of clavulanic acid.

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

11:30 am Kent Refsal / Markus Rick An update on the measurement of 21 - hydroxylase antibodies in dogs with hypoadrenocorticism

Dopamine - beta - hydroxylase requires vitamin C (ascorbic acid) and copper as cofactors.

The INRS team studied the enzymes this bacterium uses to break it down, and isolated hydroxylases as the most effective ones.

The major issue here is with dopamine B - hydroxylase which converts dopamine to Nr.

When absorbed, an enzyme called lysyl hydroxylase converts lysine into hydroxylysine.

Dop is converted to norepinephrine by the enzyme dopamine - B hydroxylase with vitamin C as the cofactor.

Lack of oxygen is sensed directly by a prolyl hydroxylase known as EGL - 9 in worms and EGLN2 in mammals.

Key aspects of ischemia - reperfusion can be modeled by a Caenorhabditis elegans behavior, the O2 - ON response, which is suppressed by hypoxic preconditioning or inactivation of the O2 - sensing HIF (hypoxia - inducible factor) hydroxylase EGL - 9.

In this study, researchers discovered a key natural variation in a β - carotene hydroxylase gene that could be used to breed cucumber with enhanced nutritional value.

The paper, by S.S. Karuppagounder at Burke Medical Research Institute in White Plains, N.Y., and colleagues was titled, «Therapeutic targeting of oxygen - sensing prolyl hydroxylases abrogates ATF4 - dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models.»

Cerebral tryptophan hydroxylase appears to have a poor affinity for oxygen and to be affected by slight hypoxia.

The research demonstrates how the two drugs, ciclopirox (anti-fungal) and deferiprone (blood treatment), effectively inhibit an enzyme called deoxyhypusine hydroxylase (DOHH).

Because the coexpression of the 24 - hydroxylase results in immediate inactivation of the intracellularly synthesized calcitriol, vitamin D functions as a rapid on - off switch for various cell responses.

He developed a Quebec - wide database tracking the incidence of genes that cause metabolic disorders, and his laboratory hosted the online phenylalanine hydroxylase locus knowledgebase, or PAHdb, a resource for scientists and clinicians.

For ABC News Dr. James Greenblatt explains that «HPHPA causes deactivation of an enzyme [Dopamine Beta - Hydroxylase] so that dopamine can not be converted to the neurotransmitter norepinephrine.»

«Voluntary ingestion of sucrose restores CRF and dopamine - beta - hydroxylase messenger RNA expression in brain, food intake, and caloric efficiency and fat deposition, circulating triglyceride, leptin, and insulin to normal.»

Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: Genetic analysis of the Milwaukee longitudinal study

Markers used included Islet - 1 and hermes for retinal ganglion cells, Tyrosine Hydroxylase for amacrine cells, R5 for Müller glia, XAP2 for rod photoreceptors, and Calbindin for cone photoreceptors (Figure 2D, 2E, 2G, and 2H; Tables S3 and S4).

91, No. 11 4205-4214 EXTENSIVE CLINICAL EXPERIENCE, Nonclassical 21 - Hydroxylase Deficiency Maria I. New Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029

Researchers at Sweden's Karolinska Institute and at the National Institutes of Health are finding a connection between tyrosine hydroxylase activity, thyroid hormone receptors, and depleted dopamine levels in the brain — particularly in the substantia nigra, a region associated with the movement difficulties characteristic of Parkinson's disease.11, 12,13

HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady - state and stress.

Niacin is synthesized from tryptophan, an essential amino acid, via the tryptophan hydroxylase pathway.

Phenylalanine in the brain is converted to tyrosine by phenylalanine hydroxylase.

We also found that Sandi was negative for 21 - hydroxylase antibodies, which causes autoimmune adrenal insufficiency.

Dopamine - beta - hydroxylase requires ascorbic acid and copper as cofactors.

Further evidence for the association between attention - deficit / hyperactivity disorder and the dopamine - beta - hydroxylase gene

This is a rare, autosomal recessive disorder caused by mutations in the gene for phenylalanine hydroxylase (PAH).

Although l - tryptophan can be obtained by eating foods that contain it, such as red meat and turkey, its ability to be converted into 5 - HTP - and ultimately into serotonin - is limited by the availability of an enzyme called tryptophan hydroxylase.

Tryptophan hydroxylase can be inhibited by many different factors, such as stress, insulin resistance, vitamin B6 deficiency and magnesium deficiency.

Dopamine - β - hydroxylase is an enzyme that is localized to catecholamine - containing vesicles in sympathetic nerves and the adrenal medulla, and is also found in the serum.