Not exact matches
In an accompanying editorial, Debra L. Weiner and Carlo Brugnara of Harvard Medical School call
for increased use of
hydroxyurea.
The committee also strongly advocates
for prescribing
hydroxyurea, an oral medication taken once daily that has become the standard of care.
Despite
hydroxyurea's proven benefits, the optimal dosing strategy
for the drug has remained controversial.
«A clinically meaningful fetal hemoglobin threshold
for children with sickle cell anemia during
hydroxyurea therapy.»
Rather than calculating a standard dose of
hydroxyurea based on patients» weight, researchers used a dose - escalation approach to determine the maximum tolerated dose
for each of the 230 St. Jude patients enrolled in the study.
Currently available treatments including
hydroxyurea, which is the only FDA approved drug
for SCA, and hemopoietic stem cell transplantation all have significant limitations, so the search
for new therapeutic options continues.