Looking inside the brains of animals exposed to chronic social defeat stress, the scientists observed
hyperactive firing of neurons in the ventral tegmental area (VTA), a critical part of a reward circuit.
When the researchers gave the mice a drug called lamotrigine, often prescribed for bipolar disorder, the animals» brain activity mimicked that
of their resilient counterparts: The
neurons in the already
hyperactive VTA started
firing even more intensely, followed by a lull and abatement
of depression symptoms.