Sentences with word «hyperexcitability»

«This work was exciting because we replicated the previous finding of neuron hyperexcitability in neurons derived from a new cohort of patients diagnosed by a different psychiatrist, confirming the robustness of this characteristic and its potential use for drug development,» says Renata Santos, co-first author and a Salk research collaborator.

Now, Klyachko and Pan-Yue Deng, MD, PhD, an assistant professor of cell biology and physiology, have identified a separate mechanism that also results in neuronal hyperexcitability: an increase in the baseline flow of sodium ions into neurons.

Working with motor neurons derived from ALS patients and healthy controls, Dr. Wainger performed fundamental electrophysiological characterization and identified motor neuron hyperexcitability in ALS patient - derived motor neurons (Wainger et al., 2014).

In epilepsy, spermine levels decrease, causing hyperexcitability.

However, detailed understanding of the molecular basis for the role of neuronal KV7 channels in hyperexcitability syndromes has been lacking.

Previous research has shown that people with cWAD can be more sensitive to pain, through an effect called central hyperexcitability.

The team found the same hyperexcitability in the lymphocyte - derived neurons, validating their earlier results.

It fits with previous research that shows mGluR5 is important for hyperexcitability, but in a different way than we had thought.»

In the absence of vitamin D, dietary calcium is not properly absorbed, resulting in hypocalcemia, leading to skeletal and dental deformities and neuromuscular symptoms, e.g. hyperexcitability.

«If hyperexcitability is the brain network basis for these symptoms, then reducing neuronal excitability with certain drugs that modulate inhibition could be of therapeutic value in these devastating neurodevelopmental disorders.»

Using whole - cell path clamp, both dSPNs and iSPNs from Q175 6 - month old mice showed elevated membrane resistance and reduced rheobase current, consistent with previous reports of SPN hyperexcitability in mouse models of HD.

Hyperexcitability as a result of this imbalance has been hypothesized to contribute to poorly functionally differentiated and inherently unstable cortex in autism (Rubenstein and Merzenich, 2003).

The purpose of this study is to investigate a new use of an allergy medicine, to reduce spasticity and muscle hyperexcitability and to evaluate the effectiveness of a new therapy using active practice of your arm and hand compared to passive stretching.

Barry G et al. (2017) The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states.

Occasionally dogs will develop hyperexcitability and drooling in response to taking cephalexin.

Dogs can develop vomiting, diarrhea, and hyperexcitability when they ingest around 9 mg of methylxanthines per pound of body weight.

According to ASPCA Poison Control, tobacco toxicity can result in hyperexcitability then depression, vomiting, incoordination, paralysis and possibly death.

Catego also contains Fipronil which we already know as effective in inducing death in fleas by creating hyperexcitability in their nervous system structures.

Nonpsychotropic Plant Cannabinoids, Cannabidivarin (CBDV) and Cannabidiol (CBD), Activate and Desensitize Transient Receptor Potential Vanilloid 1 (TRPV1) Channels in Vitro: Potential for the Treatment of Neuronal Hyperexcitability.

Mild symptoms range from lethargy and gastrointestinal upset to severe side effects that include hyperexcitability, racing heart, abnormal behavior, sedation, or seizures.

Hyperexcitability in combined entorhinal / hippocampal slices of adult rat after exposure to brain - derived neurotrophic factor

Hyperexcitability is observed in babies before and directly during a full moon but they are calmer during a descending moon.

The UCI team also uncovered that during seizures, the M - current is suppressed, which contributes to neuronal hyperexcitability.

Mutations that detrimentally affect the function of neuronal KV7 channels cause hyperexcitability syndromes such as benign familial neonatal seizures, early onset epileptic encephalopathy, and peripheral nerve hyperexcitability.

The team found that maintaining some people's neurons in a lithium - infused medium calmed this hyperexcitability.

«The fact that Gage's group can replicate the hyperexcitability characteristic in neurons from additional bipolar disorder patients is very important.

«We are initiating collaborative studies to see if we can improve some of the hyperexcitability defects we see in fragile X models, with the hope to eventually apply this new knowledge in patients with fragile X syndrome.»

«One of the properties of these neurons is increased excitability in sensitive conditions such as chronic pain and, consequently, increased sending of pain signals to the brain,» explains Lucia Hipólito, who states that the role of the small potassium channels in the hyperexcitability of spinal neurons was so far unknown.

«After a few months, it's possible that this hyperexcitability becomes too much for the cell to handle and it crashes into a less excitable state,» says Gage.

Gage and Mertens next plan to follow the affected cells for longer periods of time to see whether the hyperexcitability they measured is only an initial manic stage of the neurons» lives or is long - lasting.

If a new drug, for instance, reverses the hyperexcitability at the cellular level, it would likely treat bipolar disorder in patients.

And, he noted, since sleep is important for encoding memories and consolidating learning, this hyperexcitability of brain networks in FXS may interfere with the process of laying down new memories, and perhaps explain the learning disability in children with FXS.

That, Goel said, mirrors the hyperexcitability seen in some individuals with the syndrome.

Experimental approach: To use patient - specific induce pluripotent cell models from a (i) storage disease (NCL), (ii) aggregate prone disease (ALS) and (iii) a disease with no aggregates but hyperexcitability (ChAc) combined with state of the art live cell imaging techniques, electrophysiology and biophysical tools (PIV, laser ablation for cortex tension measurements, AFM).

We see clinical signs varying from vomiting, diarrhea (with secondary pancreatitis in severe causes), to neurologic signs which include stumbling gait, weakness or hyperexcitability, seizures to coma, and occasionally cardiac arrhythmias.

If necessary, sedation can be provided for the pet's hyperexcitability.

AMANTADINE This drug acts to modulate the pain response by antagonizing the N - methyl - d - aspartate (NMDA) receptor and the role they play in central neuronal hyperexcitability (wind up).

Other clinical signs may include fever, weakness or paralysis of hind limbs, impaired vision, ataxia, aimless wandering, walking in circles, hyperexcitability or coma.7 If horse owners notice signs or symptoms of WNV infection in their horses, they should contact a veterinarian immediately, especially if horses are exhibiting neurological signs.

If you suspect that your dog has gotten into candy or notice symptoms like vomiting, diarrhea, weakness, lethargy, hyperexcitability, or collapse, call a veterinarian immediately.

Allowing early intervention for high - risk puppies (ie, puppies removed from the litter before 8 weeks of age; that have increased fear, anxiety, and / or hyperexcitability; that have shown aggression over resources or with handling; or that have had a serious illness before 4 months of age)

Other side effects of cephalosporins include allergic reaction, increased salivation, hyperexcitability, and with high doses, or rarely: kidney toxicity, severe skin reactions, neurologic symptoms, or blood cell changes.

Other clinical signs may include fever, weakness or paralysis of hind limbs, impaired vision, ataxia, aimless wandering, walking in circles, hyperexcitability or coma.6 If horse owners notice signs or symptoms of West Nile infection in their horses, they should contact a veterinarian immediately.