Female maternal HFD offspring presented lower insulin sensitivity and fasting
hyperglycemia compared with controlled littermates after birth (148).
Not exact matches
Further analysis revealed that the mice in Tg / Tg group, which developed severe
hyperglycemia, lost > 75 % of their β cells
compared with WT mice of the same strain and similar age.
Although prospective randomized long — term clinical studies
comparing the effects of conventional and intensive therapy have demonstrated a clear link between diabetic
hyperglycemia and the development of secondary complications of diabetes, they have not defined the mechanism through which excess glucose results in tissue damage.