An article published late last year by Dr. Ingenbleek entitled «The Oxidative Stress
of Hyperhomocysteinemia Results from Reduced Bioavailability of Sulfur - Containing Reductants» expands upon the issues raised in the Nutrition article.
The correlation of B12 deficiency
with hyperhomocysteinemia could well reach statistical significance if a larger groups of subjects were studied.»
Herrmann W, Schorr H, Obeid R, Geisel J. Vitamin B - 12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and
hyperhomocysteinemia in vegetarians.
Dr. Ingenbleek is well known for his work on malnutrition, the essential role of sulfur to nitrogen, and sulfur deficiency as a cause
of hyperhomocysteinemia.
The correlation of B12 deficiency
with hyperhomocysteinemia could well reach statistical significance if a larger group of subjects were studied.»
For this reason, several large ‐ scale clinical trials were initiated to test the hypothesis that lowering homocysteine with folic acid and vitamin B12 can reduce the risk of atherothrombotic events in individuals with established vascular disease and
hyperhomocysteinemia.
Hyperhomocysteinemia, a know risk factor for atherothrombosis, can be treated by facilitating the methylation of homocysteine to methionine.
Research Interests: One - carbon metabolism; methionine cycle; transsulfuration; micronutrients; vitamin B12 (cobalamins); folates; homocysteine; homocystinuria;
hyperhomocysteinemia; diagnosis of cobalamin deficiency; atherogenesis; endothelial cell dysfunction; alcoholic liver disease; biomarkers of one - carbon metabolism.
Deficiencies of either of the 2 micronutrients, will lead to
hyperhomocysteinemia and, in severe cases, homocystinuria.
The 2012 Nutrition study15 also concluded that the low intake of sulfur amino acids by vegetarians and vegans explains the origin of
hyperhomocysteinemia (high blood levels of homocysteine, which may lead to blood clots in your arteries — i.e. heart attack and stroke) and the increased vulnerability of vegetarians to cardiovascular diseases.
It is therefore likely that
the hyperhomocysteinemia status of some of our rural subjects in the present survey might have resulted from combined B12 and protein deficiencies.
The title alone, «Vegetarianism produces subclinical malnutrition,
hyperhomocysteinemia and atherogenesis,» sounds a significant warning.
However, as the researchers point out, «A previous study undertaken in the same Chadian area in a larger group of sixty rural participants did demonstrate a weak inverse correlation between B12 and homocysteine concentrations in the twenty subjects most severely protein depleted... It is therefore likely that
the hyperhomocysteinemia status of some of our rural subjects in the present survey might have resulted from combined B12 and protein deficiencies.
The title alone — «Vegetarianism produces subclinical malnutrition,
hyperhomocysteinemia and atherogenesis» — sounds a significant warning.
Dr. Ingenbleek is well known for his work on malnutrition, the essential role sulfur plays along with nitrogen in metabolism, and sulfur deficiency as a cause of
hyperhomocysteinemia.
«
Hyperhomocysteinemia» as elevated levels are termed, seems to crank up the formation of free radicals through a variety of dangerous interactions with proteins, chemicals and the cells in the body.
Its title «Vegetarianism produces subclinical malnutrition,
hyperhomocysteinemia and atherogenesis» sounded a strong warning about heart disease risk, and the article itself detailed why subjects on mostly vegan diets can develop morbidity and mortality from cardiovascular disease unrelated to vitamin B status and Framingham criteria.
However, when methionine - rich diets are used to induce
hyperhomocysteinemia... Mice fed methionine - rich diets had significant atheromatous pathology in the aortic arch even with normal plasma homocysteine levels, whereas mice fed B vitamin - deficient diets developed severe hyperhomocysteinemia without any increase in vascular pathology.
Vitamins B6, B12, and folate are especially important for lowering our risk of
hyperhomocysteinemia (excessive formation of homocysteine), and by making a large contribution to our folate intake, cruciferous vegetables can help us lower our risk of all three cardiovascular diseases.
A prospective study in 816 elderly men and women reported that those with
hyperhomocysteinemia (homocysteine levels > 15 μmol / L) had a significantly higher risk of developing Alzheimer's disease or dementia.
Association of prehypertension and
hyperhomocysteinemia with subclinical atherosclerosis in asymptomatic Chinese: a cross-sectional study