Since this occurs only in those rare pituitary tumours, we will ignore this, since its prevalence pales in comparison to the epidemic of
hyperinsulinemia in current Western civilization.
Listed below is the progression from health to disease,
with hyperinsulinemia building progressively throughout.
In this study, we extended this picture further, since the compensatory effect of
hyperinsulinemia on GS in diabetic cultures can be eliminated at supraphysiological insulin concentrations, which induce insulin resistance in diabetic as well as control cultures.
That's what they did in the next paper «Production of insulin resistance
by hyperinsulinemia in man» Diabetologia 28:70 — 75, 1985 Rizza RA.
I remember Dr. Rosedale speaking of how there are genetic differences in how much insulin is released in response to carbs and that the people who have higher insulin responses to meals are prone to developing
hyperinsulinemia over time.
Symptoms of PPID include changes in hair coat; increased water intake and urination; lethargy; loss of muscle mass, pot - bellied appearance, chronic infections; hoof abscesses; excess or inappropriate sweating; infertility or lack of estrus cycles; abnormal mammary gland function; and can predispose to laminitis
if hyperinsulinemia (high levels of insulin in the blood) is involved.
Beyond genetics, a powerful risk factor for developing AD is chronically elevated insulin, also
called hyperinsulinemia.
«Effect of sustained
physiologic hyperinsulinemia and hyperglycemia on insulin secretion and insulin sensitivity in man» Diabetologia Oct1994, Vol37, Iss 10, 1025 - 1035 Del Prato S.
This explains how many primitive societies could tolerate extremely high carbohydrate diets without
developing hyperinsulinemia or insulin resistance.
This model allowed the researchers to study the effects of
hyperinsulinemia without the confounding effects of insulin resistance.
Women with PCOS and
hyperinsulinemia typically have higher levels of testosterone and suffer from mild acne to increased hair on their face, neck and abdomen.
Prenatal Testosterone Exposure Leads to Gonadal Hormone -
Dependent Hyperinsulinemia and Gonadal Hormone - Independent Glucose Intolerance in Adult Male Rat Offspring.
Cultures were exposed to increasing concentrations of insulin for 4 days to clarify whether they express genetic and / or insulin - induced insulin resistance by
hyperinsulinemia at the level of GS or glucose transport.
The polycystic ovary syndrome (PCOS) describes a female - specific state of androgen excess and
hyperinsulinemia related to obesity, T2DM, and higher cardiometabolic risk (72, 73).
However, the Joslin study, published in the May issue of the journal Arteriosclerosis, Thrombosis, and Vascular Biology, shows that, without other factors such as high blood pressure and high cholesterol,
hyperinsulinemia alone does not cause atherosclerosis.
The results were that the mice were protected
against hyperinsulinemia, obesity, hepatis steatosis, various organ inflammations and had their motor coordination increased, despite consuming the same amount of calories in comparison to the control group of mice that were allowed to consume their food whenever they preferred throughout the day.
Well, many with a good (low) insulin response at the start will inevitably drift
into hyperinsulinemia over time, given our ridiculous food supply since the 1970's.
The phenomenon of resistance depends not only
upon hyperinsulinemia, but also upon the persistence of those elevated levels.
Often I
heard hyperinsulinemia referred to as something influenced by diet, namely carbohydrate levels in the diet, but I wondered if this were truly the only influence.
Hyperinsulinemia appears to increase the effect of luteinizing hormone (LH) to increase androgen production (testosterone) which produces many of the clinical effects of PCOS.