The hyperintensity of both the DN and the GP correlated with the number of Gd - CM administrations.
The precise clinical ramifications of hyperintensity are not known, but hyperintensity in the DN has been associated with multiple sclerosis, while
hyperintensity of the GP is linked with hepatic dysfunction and several diseases.
«
The hyperintensity of DN and GP on unenhanced T1WI may be due to gadolinium deposition in the brain independent of renal function, and the deposition may remain in the brain for a long time,» Dr. Kanda suggested.
Dr. Kanda noted that because patients with multiple sclerosis tend to undergo numerous contrast - enhanced brain MRI scans,
the hyperintensity of the DN seen in these patients may have more to do with the large cumulative gadolinium dose than the disease itself.
(b) Sagittal proton density - weighted MR image of left foot confirms fracture line and periosteal reaction (arrow), and also shows diffuse
hyperintensity of entire metatarsal confirming acute nature of stress fracture.
Not exact matches
Patients showing gadolinium in the vitreous chamber at the later timepoint tended to be
of older age, have a history
of hypertension, and have more bright spots on their brain scans, called white matter
hyperintensities, that are associated with brain aging and decreased cognitive function.
Over time, «significant and persistent» MRI abnormalities (called T1 - weighted signal
hyperintensities) developed in the brains
of rats receiving the linear GBCA, gadodiamide.
However, in recent years, clinicians in Japan noticed that patients with a history
of multiple administrations
of Gd - CM showed areas
of high intensity, or
hyperintensity, on MRI in two brain regions: the dentate nucleus (DN) and globus pallidus (GP).
Seven years later, the volume
of white matter
hyperintensities was determined using brain MRI.
«Our results demonstrate that aortic arch pulse wave velocity is a highly significant independent predictor
of subsequent white matter
hyperintensity volume and provides a distinct contribution — along with systolic blood pressure, hypertension treatment, congestive heart failure and age — in predicting risk for cerebrovascular disease,» Dr. King said.
The researchers also analyzed 15 other cardiovascular risk factors, as well as age, gender and ethnicity, as predictors
of white matter
hyperintensities.
The results showed that aortic arch pulse wave velocity helped predict white matter
hyperintensity volume, independent
of the other demographic and cardiovascular risk factors.
BACKGROUND AND PURPOSE White - matter
hyperintensities (WMHs) detected by magnetic resonance imaging are thought to represent the effects
of cerebral small - vessel disease and neurodegenerative changes.
Spatial distribution
of white - matter
hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging.
Relative risk values
of age, acrolein, IL - 6 and CRP as markers
of periventricular
hyperintensities: a cross-sectional study
Negativity can come in the form
of cynicism, criticism, whining, attacking, pessimism, discontent, perfectionism, and
hyperintensity.