The end result of the research was that there was a common gene mutation that was responsible for footpad
hyperkeratosis in all the breeds involved in the research project.
«I am contacting you to let you know that we have performed a study to look at Hereditary Footpad
Hyperkeratosis in the Bedlington Terrier.
Not exact matches
EFFECT: Decreased circulating androgens Male and female infertility: Decreased sperm production
in males; fetal loss
in females Genital malformations Cleft palate and various birth defects Immune suppression
Hyperkeratosis and other skin diseases Growth retardation Increased mortality
In the future I will explore this with a full and detailed post that will enable you to sort out
hyperkeratosis for good.
Hyperkeratosis causes your dead skin cells to stick together, form massive clumps and then get lodged firmly
in your pores.
Idiopathic digital
hyperkeratosis usually occurs
in dogs older than 10.
However,
in August 2008 Professor Tosso Lieb and a team of geneticists at the University of Berne,
in conjunction with ANTAGENE, started a research project to analyse the genomes of a number of breeds of dog (including the Irish terrier, but not the Bedlington terrier)
in which footpad
hyperkeratosis was a problem.
The Health Group felt that the statement
in relation to «feet» used
in Breed Watch documentation was too general and did not reflect the nature of the problem (Footpad
Hyperkeratosis)
in Bedlington terriers and, incidentally,
in Irish terriers.
References DVM 360: Localized Keratinization Syndromes (Proceedings) Animal Dermatology Clinic of British Columbia: Paw and Nail Disorders McKeever Dermatology Clinics: Nasal and Digital
Hyperkeratosis petMD: Inflammatory Skin Disease
in Dogs Vetstream: Skin — Keratinization disorders University of Prince Edward Island: What is Seborrhea?
Hereditary footpad
hyperkeratosis is an autosomal recessive skin condition found
in certain breeds of dogs
in which the foot pads become hardened, losing their normal elasticity, developing painful cracks that are prone to infections that can lead to lameness.
Signs of a vitamin A deficiency
in cats are similar to those
in other species, except that classic xerophthalmia, follicular
hyperkeratosis, and retinal degeneration are rarely seen and usually are associated with concomitant protein deficiency.
The first is a condition which affects the nose and feet, called Nasodigital
Hyperkeratosis,
in which the keratin
in the nose and paw pads develops into a tough, fibrous growth — often resembling callusing.
In hyperkeratosis, keratin - the tough, fibrous outer covering of foot pads - grows excessively.
In some cases,
hyperkeratosis of the nose and footpads may be seen (the nose and footpads become very thickened and cracked — see photo).
(Kennel Club Press Release) The Kennel Club has approved a new official DNA testing scheme for Hereditary Footpad
Hyperkeratosis (HFH)
in Irish Terriers, following consultation with breed clubs.
Typical signs of canine distemper seen
in the domestic dog include respiratory and intestinal problems such as coughing, diarrhoea, vomiting, nasal and ocular discharge, anorexia, and
hyperkeratosis of the nasal planum and foot pads.
Cutaneous lesions include
hyperkeratosis, follicular keratosis, hyperpigmentation, adnexal atrophy, loss of elastin fibers, and a loose network of collagen fibers
in the dermis.
In some dogs there may be a genetic predisposition to
hyperkeratosis.