Sentences with word «hypermethylation»

Promoter hypermethylation of tissue specific tumor supressor genes and point mutation in K - ras, c - myc proto - oncogenes in urinary (transitional cell) bladder carcinoma

DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation.

Inactivation of the tumor suppressor gene RASSF1A by promoter hypermethylation represents a key event underlying the initiation and progression of lung cancer.

If a glucose deficiency caused RXRA hypermethylation and glucose excess caused RXRA, there would have been a much larger scatter in RXRA methylation levels among the low - carb quartile compared to the 3 higher - carb quartiles.

Atrial fibrillation is associated with hypermethylation in human left atrium, and treatment with decitabine reduces atrial tachyarrhythmias in spontaneously hypertensive rats.

By contrast, in more than 90 % of endometrial cancers, the gene has undergone hypermethylation, an epigenetic modification that doesn't change its DNA sequence but renders it inactive.

The research team estimates that verification and use of the new hypermethylation test is years away, and the cMethDNA assay is not yet available for general use.

The test searches for evidence of so - called hypermethylation, a type of chemical tag affixed to DNA in one or more of six breast cancer - specific genes.

Biologically, hypermethylation often silences genes that keep runaway cell growth in check, and its appearance in the DNA code of breast cancer - related genes shed into the blood may indicate that a patient's cancer growth is increasing and the disease has worsened.

In KYSE 510 cells, p16INK4a, RARβ, MGMT, and hMLH1 had hypermethylation status with the loss of the respective mRNA expression.

Setdb1 - mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2 - deficient mice.

Smoking was not associated with p16 or ppENK hypermethylation.

The new study found significant hypermethylation in the most aggressive meningiomas, and showed that these DNA modifications specifically silenced genes that usually inhibit FOXM1 expression and Wnt signaling.

Nevertheless, there has always been the nagging question: Does tumor hypermethylation at the p16 locus cause or result from cancer formation?

The authors demonstrate that hypermethylation upstream of the maternally inherited allele correlates with a severe version of the disease, congenital myotonic dystrophy.

Genetic Changes Outside Nuclear DNA Suspected to Trigger More Than Half of All Cancers A buildup of chemical bonds on certain cancer - promoting genes, a process known as hypermethylation, is widely known to render cells cancerous by disrupting biological brakes on runaway growth.

But Spector argues that EpiTwin has already made valuable contributions — for example, through a study of 15 twin pairs discordant for breast cancer that pointed toward hypermethylation of the DOK7 gene, which he believes could one day be used as a biomarker to help identify women at risk for breast cancer years in advance.

Indeed, long term outcome studies using this approach are lacking, and research suggests caution is advised with regard to imbalanced hypermethylation.

Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»

This conundrum appeared to be resolved in 1995 by the finding that p16 function is often inactivated in tumors by promoter hypermethylation (Merlo et al. 1995).

So it could be maternal smoking, lack of exercise, or drinking too much alcohol or caffeine that causes RXRA hypermethylation and childhood obesity.

The paper gives us essentially no evidence at all as to what causes hypermethylation of RXR - alpha in the womb, except that it correlates with low carbohydrate consumption in the women of Southampton UK.

RUNX3 Is Frequently Inactivated by Dual Mechanisms of Protein Mislocalization and Promoter Hypermethylation in Breast Cancer

Hypermethylation can promote tumor growth; that may explain why, in a separate study, Spanish researchers in 2012 found higher rates of cancer among adult sleep apnea patients.

The researchers found that hypermethylation and silencing of the Cdkn2a locus ultimately led to loss of the tumor suppressor proteins p16 and p19.

But the mechanism isn't perfect: «If you look at tumors, they tend to have hypomethylation overall, but hypermethylation in some genes,» Sapienza says.

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).

The inhibition of DNMT, especially DNMT1, would block the hypermethylation of the newly synthesized DNA strand, resulting in the reversal of the hypermethylation and the re-expression of the silenced genes (11, 12, 13).

The reversal of hypermethylation and re-expression of these four genes by EGCG was similar to that produced by the classical DNMT inhibitor, DAC.

It is likely that inhibition of DNMT and histone deacetylase can also prevent the hypermethylation and silencing of these key genes and, therefore, this inhibition would contribute to the prevention of carcinogenesis.

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes including those for tumor suppressors, DNA repair enzymes, and receptors (5, 6, 7, 8).

In plasma DNA of 83 patients with untreated primary pancreatic ductal adenocarcinoma, DNA hypermethylation was determined by methylation - specific polymerase chain reaction and K - ras codon 12 mutations by enriched - nested polymerase chain reaction followed by direct sequencing.

K - ras mutations, ppENK, and p16 promoter hypermethylation were detected in 32.5 %, 29.3 %, and 24.6 % of the patients, respectively.

In breast cancer, several known cancer genes, such as BRCA1 and CDH1 (E-cadherin) are commonly silenced by hypermethylation.

Together, these findings suggest that hypermethylation may be an early trigger that leads to the development of aggressive forms of meningioma.

Previous research has identified excessive methylation of DNA, or «hypermethylation,» as a ubiquitous aspect of cancer development.

He noted that there are some ongoing studies that may further inform this difference in the future, including tumor DNA analysis with whole exome sequencing and tumor RNA analysis with RNAseq, evaluation of circulating cell - free tumor DNA, and hypermethylation.

Prognostic Significance of Promoter Hypermethylation and Diminished Gene Expression of SYNPO2 in Melanoma.

In mouse embryo fibroblasts (MEFs)[2], as well as in the PCa cell lines [unpublished data], DAXX represses expression of these genes via mechanisms that include its binding to DNA methyl transferases (DNMTases) and hypermethylation of the promoter regions of the corresponding genes [2].

14 March 2015: Hypermethylation of the promoter region of p16 causes cancer and reduces survival in mice according to a recent report by Lanlan Shen and her colleagues in The Journal of Clinical Investigation.

Hypermethylation of the promoter region of p16 causes cancer and reduces survival in mice according to a recent report by Lanlan Shen and her colleagues in The Journal of Clinical Investigation.

So there is likely to be some other factor besides carbohydrate intake that was responsible for the RXRA hypermethylation.

The paper presents solid evidence that hypermethylation of RXR - alpha in the womb predisposes children to become obese at age 9.