Sentences with phrase «hypermethylation of»

Promoter hypermethylation of tissue specific tumor supressor genes and point mutation in K - ras, c - myc proto - oncogenes in urinary (transitional cell) bladder carcinoma

The paper gives us essentially no evidence at all as to what causes hypermethylation of RXR - alpha in the womb, except that it correlates with low carbohydrate consumption in the women of Southampton UK.

But Spector argues that EpiTwin has already made valuable contributions — for example, through a study of 15 twin pairs discordant for breast cancer that pointed toward hypermethylation of the DOK7 gene, which he believes could one day be used as a biomarker to help identify women at risk for breast cancer years in advance.

In mouse embryo fibroblasts (MEFs)[2], as well as in the PCa cell lines [unpublished data], DAXX represses expression of these genes via mechanisms that include its binding to DNA methyl transferases (DNMTases) and hypermethylation of the promoter regions of the corresponding genes [2].

The inhibition of DNMT, especially DNMT1, would block the hypermethylation of the newly synthesized DNA strand, resulting in the reversal of the hypermethylation and the re-expression of the silenced genes (11, 12, 13).

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).

Not exact matches

By contrast, in more than 90 % of endometrial cancers, the gene has undergone hypermethylation, an epigenetic modification that doesn't change its DNA sequence but renders it inactive.

Biologically, hypermethylation often silences genes that keep runaway cell growth in check, and its appearance in the DNA code of breast cancer - related genes shed into the blood may indicate that a patient's cancer growth is increasing and the disease has worsened.

The reversal of hypermethylation and re-expression of these four genes by EGCG was similar to that produced by the classical DNMT inhibitor, DAC.

The scientists then used statistical models to evaluate the distribution of cancer - linked DNA in the patients» blood samples over the seven - year study to find the largest degree of differences between patients with low and high levels of evidence of hypermethylation in their DNA.

In KYSE 510 cells, p16INK4a, RARβ, MGMT, and hMLH1 had hypermethylation status with the loss of the respective mRNA expression.

Setdb1 - mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2 - deficient mice.

K - ras mutations, ppENK, and p16 promoter hypermethylation were detected in 32.5 %, 29.3 %, and 24.6 % of the patients, respectively.

Inactivation of the tumor suppressor gene RASSF1A by promoter hypermethylation represents a key event underlying the initiation and progression of lung cancer.

DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation.

Together, these findings suggest that hypermethylation may be an early trigger that leads to the development of aggressive forms of meningioma.

Previous research has identified excessive methylation of DNA, or «hypermethylation,» as a ubiquitous aspect of cancer development.

He noted that there are some ongoing studies that may further inform this difference in the future, including tumor DNA analysis with whole exome sequencing and tumor RNA analysis with RNAseq, evaluation of circulating cell - free tumor DNA, and hypermethylation.

RUNX3 Is Frequently Inactivated by Dual Mechanisms of Protein Mislocalization and Promoter Hypermethylation in Breast Cancer

Prognostic Significance of Promoter Hypermethylation and Diminished Gene Expression of SYNPO2 in Melanoma.

Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»

In cancers, aberrant promoter CpG island hypermethylation correlates highly with gene inactivation and can account for lack of gene expression where mutations do not exist.

So it could be maternal smoking, lack of exercise, or drinking too much alcohol or caffeine that causes RXRA hypermethylation and childhood obesity.