Sentences with phrase «hypermethylation often»
Biologically, hypermethylation often silences genes that keep runaway cell growth in check, and its appearance in the DNA code of breast cancer - related genes shed into the blood may indicate that a patient's cancer growth is increasing and the disease has worsened.
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This conundrum appeared to be resolved in 1995 by the finding that p16 function is often inactivated in tumors by promoter hypermethylation (Merlo et al. 1995).