Sentences with phrase «hypermutation of»

Peters A, Storb U. Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.

Shen H, Peters A, Baron B, Zhu X, Storb U. Mutation of BCL - 6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

In germinal centers — the sites within lymph nodes where mature B cells cluster — B cells proliferate and undergo hypermutation of their antibody genes to generate high - affinity antibodies.

Not exact matches

The authors highlight an intriguing finding, which was that the level of antibody tinkering — known as somatic hypermutation — did not increase in volunteers» B cells over time after seasonal flu immunization.

Plasmablasts induced by pandemic H1N1 infection are highly cross-reactive and have accumulated particularly high levels of variable gene somatic hypermutation.

(D) The average number of somatic hypermutations in the pandemic H1N1 patient plasmablast variable region genes compared with primary IgG plasmablast responses to vaccinia (small pox) or the anthrax vaccine, or after at least 4 boosters with the anthrax vaccine.

The short size of the locus was ideal for 454 sequencing, and because single - molecule reads are generated, the authors were able to identify haplotypes of somatic hypermutations carried by individual leukemic cells.

(PMID: 8574852) Storb U. Progress in understanding the mechanism of somatic hypermutation.

Andy Peters and Ursula Storb show that the initiation of Ig gene transcription targets Ig gene somatic hypermutation (SHM), by duplicating the variable (V) region promoter upstream of the constant (C) region and showing that a second wave of mutations occurs over the C region.

Dr. Honjo is well known for his discovery of activation - induced cytidine deaminase that is essential for class switch recombination and somatic hypermutation.

Our pioneering next - generation sequencing assay kits and software are revolutionizing the detection of clonality, somatic hypermutation, and minimal residual disease (MRD).

Our NGS kits are used to detect clonal gene rearrangements, somatic hypermutations and for the study of MRD.

It appears that the change in germine - encoded repertoire and the decrease of somatic hypermutation represent distinct mechanisms of immunosenescence and that the aging of helper T cells plays a pivotal role in both of these processes.

In particular, she identified a novel phenomenon of localised hypermutation termed «kataegis».

Iterative cycles of hypermutation and selection continue until antibodies of high antigen binding specificity emerge (affinity maturation).

Another research group [16] used hypermutation in a similar way in Ramos cells to evolve mRFP1.2 (excitation / emission peaks of 590/612 nm) to mPlum (590/649 nm) and mRaspberry (598/625 nm).

Scheme representing the phenomenon of X chromosome hypermutation (Jäger et al., 2013 Cell).