Sentences with phrase «hypermutation process»

In contrast, the somatic hypermutation process in the GC B cells followed a different pattern.

Recent studies in mice suggested that antibodies produced by old individuals may be encoded by distinct immunoglobulin (Ig) genes and that the somatic hypermutation process in these individuals is compromised.

Not exact matches

Mutations can be caused by copying errors in the genetic material during cell division and by exposure to radiation, chemicals, or viruses, or can occur deliberately under cellular control during the processes such as meiosis or hypermutation.

Normally, within the llama, these antibodies would adapt to a new antigen (via a process called somatic hypermutation), but the researchers could not inject the animals with cholera and wait for them to create the correct antibodies.

Shen H, Peters A, Baron B, Zhu X, Storb U. Mutation of BCL - 6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

It appears that the change in germine - encoded repertoire and the decrease of somatic hypermutation represent distinct mechanisms of immunosenescence and that the aging of helper T cells plays a pivotal role in both of these processes.