Sentences with phrase «hypermutations in»

(D) The average number of somatic hypermutations in the pandemic H1N1 patient plasmablast variable region genes compared with primary IgG plasmablast responses to vaccinia (small pox) or the anthrax vaccine, or after at least 4 boosters with the anthrax vaccine.

Another research group [16] used hypermutation in a similar way in Ramos cells to evolve mRFP1.2 (excitation / emission peaks of 590/612 nm) to mPlum (590/649 nm) and mRaspberry (598/625 nm).

Not exact matches

The authors highlight an intriguing finding, which was that the level of antibody tinkering — known as somatic hypermutation — did not increase in volunteers» B cells over time after seasonal flu immunization.

Mutations can be caused by copying errors in the genetic material during cell division and by exposure to radiation, chemicals, or viruses, or can occur deliberately under cellular control during the processes such as meiosis or hypermutation.

In germinal centers — the sites within lymph nodes where mature B cells cluster — B cells proliferate and undergo hypermutation of their antibody genes to generate high - affinity antibodies.

Shen H, Peters A, Baron B, Zhu X, Storb U. Mutation of BCL - 6 gene in normal B cells by the process of somatic hypermutation of Ig genes.

More specifically, rabbits have two antibodies in affinity maturation mechanisms: gene conversion and hypermutation, as opposed to mice where no gene conversion occurs.

(PMID: 8574852) Storb U. Progress in understanding the mechanism of somatic hypermutation.

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Recent studies in mice suggested that antibodies produced by old individuals may be encoded by distinct immunoglobulin (Ig) genes and that the somatic hypermutation process in these individuals is compromised.

It appears that the change in germine - encoded repertoire and the decrease of somatic hypermutation represent distinct mechanisms of immunosenescence and that the aging of helper T cells plays a pivotal role in both of these processes.

In contrast, the somatic hypermutation process in the GC B cells followed a different patterIn contrast, the somatic hypermutation process in the GC B cells followed a different patterin the GC B cells followed a different pattern.

In particular, she identified a novel phenomenon of localised hypermutation termed «kataegis».

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