In a study led by Alexander Pines, a senior faculty scientist with Berkeley Lab's Materials Sciences Division and UC Berkeley's Glenn T. Seaborg Professor of Chemistry, researchers recorded the first bulk room - temperature NMR
hyperpolarization of carbon - 13 nuclei in diamond in situ at arbitrary magnetic fields and crystal orientations.
«Our results in this study represent an NMR signal enhancement equivalent to that achieved in the pioneering experiments of Lucio Frydman and coworkers at the Weizmann Institute of Science, but using microwave - induced dynamic
nuclear hyperpolarization in diamonds without the need for precise control over magnetic field and crystal alignment,» Pines says.
The authors believe this new
hyperpolarization technique should enable orders of magnitude sensitivity enhancement for NMR studies of solids and liquids under ambient conditions.
In our paper we demonstrate an efficient scheme that realises laser induced 13C nuclear spin
hyperpolarization in a bulk diamond at room temperature and low ambient magnetic field.
The paper is titled «Room - temperature in situ nuclear
spin hyperpolarization from optically pumped nitrogen vacancy centers in diamond.»
The research group of Alex Pines has recorded the first bulk room - temperature
NMR hyperpolarization of carbon - 13 nuclei in diamond in situ at arbitrary magnetic fields and crystal orientations.
The purpose of this study was to investigate the feasibility of in vivo 13C → 1H
hyperpolarization transfer, which has significant potential advantages for detecting the distribution and metabolism of hyperpolarized 13C probes in a clinical MRI scanner.
«Diamonds may be the key to future NMR / MRI technologies: Researchers increase NMR / MRI sensitivity
through hyperpolarization of nuclei in diamond.»
Here we propose and analyze in detail protocols that can achieve
rapid hyperpolarization of 13C nuclear spins in randomly oriented ensembles of nanodiamonds at room temperature.
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Toward Hyperpolarization of Oil Molecules via Single Nitrogen Vacancy Centers in Diamond, Nano Letters, 18, 1882 (2018)
This class of drugs selectively binds to glutamate-gated and gamma - aminobutyric acid (GABA)- gated chloride channels in the mite's nervous system, resulting in
cell hyperpolarization, mite paralysis, and, finally, death.
This compound works by opening certain channels in the neurons and muscle cells of susceptible organisms which results in
cellular hyperpolarization.
Together with efficient Auger photoionization, these resolved hyperfine transitions permit rapid
nuclear hyperpolarization and electrical spin - readout.
This leads to
hyperpolarization of the cell membrane which, in turn, cause paralysis or the cessation of neuromuscular activity.
They found that altering the activity of three specific targets — GABAB currents, the potassium leak currents and
hyperpolarization - activated thalamic currents — restored sleep patterns in their model.
Surprisingly, altering just the potassium leak currents or
the hyperpolarization - activated thalamic currents could also restore normal deep sleep wave patterns.
Furthermore,
this hyperpolarization was achieved with microwaves, rather than relying on precise magnetic fields for hyperpolarization transfer.
«
Our hyperpolarization technique based on optically polarized NV centers is far more robust and efficient and should be applicable to arbitrary target molecules, including biological systems that must be maintained at near ambient conditions.»
«We therefore use a relatively new method,
hyperpolarization,» explains Stephan Düwel, physicist and first author of the study.
The biosensor is injected intravenously into the organism, then the MRI scan has to be made immediately: It only takes 60 seconds for the signal - amplifying effect of
the hyperpolarization to wear off again.
The Climate Debate,
the hyperpolarization of politics, and even the resurgence of racist rhetoric, and the ensuing discussions, such as this, of bias and finger pointing, has become all the rage.
In this case, the subject is climate change policy, but the fissures being exposed are relevant to all of left politics in an age of
hyperpolarization.