Sentences with phrase «hypersensitive sites»

Parental allele - specific hypersensitive sites at DMRs are likely to indicate binding of non-histone proteins to the unmethylated chromosome.

At this differentially methylated imprinting - control region, we detected constitutive DNase - I hypersensitive sites (HS) and a non-nucleosomal chromatin organization on the unmethylated maternal chromosome (see contribution of S. Khosla).

Such an allelic chromatin organization might be present at other DMRs as well, and a recent study by Schweizer et al. (2) shows that the imprinting - control region in the 5 % portion of the SNRPN gene has strong hypersensitive sites on the unmethylated maternal chromosome only.

Sequencing the cut - points of DNase I (DNase - Seq) identifies these DNAse I hypersensitive sites (DHSs), which are about 200 bp long.

Sequencing of DNase I hypersensitive sites in (125 cell types), FAIRE analysis of reduced nucleosome crosslinking (25 cell types), and genomic DNase I footprinting (41 cell types).

The DNase I data exploits a structural feature of regulatory DNA that's been known for decades: the binding of sequence - specific transcriptional regulators in place of nucleosomes creates DNase I hypersensitive sites, or DHSs.

Mutations were also enriched in DNase I hypersensitive sites (DHSs), which represent likely regulatory regions.

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