November 14, 2006 Anti-cancer drug shows early promise in pulmonary
hypertension A drug used to treat kidney cancer can prevent the development of pulmonary hypertension (high blood pressure in the lungs) in rodents, report researchers from the University of Chicago at the 2006 annual meeting of the American Heart Association, November 12 to15, in Chicago.
Not exact matches
Lisinopril is type of
drug called an ACE inhibitor that's
used to treat heart conditions including
hypertension and congestive heart failure.
Potential subjects were accepted into the study if they had none of the following conditions: severe or symptomatic cardiac disease or
hypertension; history of bleeding disorders; chronic history of gastric, intestinal, liver, pancreatic, or renal disease; any portion of the stomach or the intestine removed (other than an appendectomy); history of intestinal obstruction, malabsorption, or
use of antacid
drugs; cancer (active or
use of medications for a history of cancer treatment within the past 5 y); history of chronic alcoholism; a convulsive disorder; or abnormal results in screening blood or urine samples.
Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking
Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems
Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women
(borrowed from Dr Kitty) Breech Twins and higher order multiples Previous CS Pre-Eclampsia Placenta praevia Cervical incompetence Previous late stillbirth Previous premature birth Grand multiparty Age under 18 Age over 35 Smoking
Drug use Severe mental health issue Epilepsy Type 1 diabetes Type 2 diabetes Gestational diabetes Asthma GBS positive Abnormal antibodies Transplant recipient Congenital heart disease Known foetal abnormality Immunosuppressive medication MS Physical disability Intellectual disability Hypothyroidism Hyperthyroidism Previous shoulder dystocia Previous 3rd or 4th degree tear Sickle Cell anaemia BMI under 18 or over 35 at conception Previous massive PPH APH in current pregnancy HIV / AIDS Hepatitis B or C Active TB IUGR Oligohydramnios Polyhydramnios Child previously removed from custody because of abuse Uterine abnormalities such as uterine septum or double uterus Previous uterine surgery for fibroids Chronic renal problems
Hypertension Auto immune condition Previous stroke or blod clot Cancer Domestic violence or abusive home Prisoners Homeless women
Exclusion criteria for mothers: medical conditions such as diabetes or
hypertension;
drug use that could impair breastfeeding
The resulting
drug, named captopril, is now commonly
used to treat
hypertension and certain cardiac diseases.
Women were also excluded from the analysis if the first prenatal visit was after 20 weeks gestation or if the mother self - reported diabetes,
hypertension, known human immunodeficiency virus status, or
use of illicit
drugs or cigarettes during pregnancy.
Hydrochlorothiazide is a frequently
used drug to treat
hypertension, which is typically
used in combination with other antihypertensive medicines.
The study, which is published today in the Journal of Clinical
Hypertension and is supported by Barts Charity, devised a novel treatment strategy for 55 patients, involving fractional dosing with tablets (halving or quartering pills), liquid formulations of antihypertensive
drugs and patch formulations of antihypertensive
drugs — plus
use of unlicensed
drugs that lower blood pressure.
Mads E. Jørgensen, M.B., of Gentofte Hospital, University of Copenhagen, Denmark and coauthors examined in - hospital records and out - of - hospital pharmacotherapy
use in Danish patients with uncomplicated
hypertension treated with at least two antihypertensive
drugs (β - blockers, thiazides, calcium antagonists or renin - angiotensin system [RAS] inhibitors) undergoing noncardiac surgery between 2005 and 2011.
Inhaled Nitric Oxide (iNO) is a
drug approved by the Food and Drug Administration that is commonly used in term and near - term neonates who have severe respiratory failure caused by pulmonary hypertens
drug approved by the Food and
Drug Administration that is commonly used in term and near - term neonates who have severe respiratory failure caused by pulmonary hypertens
Drug Administration that is commonly
used in term and near - term neonates who have severe respiratory failure caused by pulmonary
hypertension.
Schiffrin argues that these
drugs are too risky to
use in
hypertension, which people can live with for decades.
• Patients must have adequate coagulation (international normalized ratio (INR) or prothrombin time (PT), partial thromboplastin time (PTT) ≤ 1.5 times ULN) • Adequate liver function (total bilirubin ≤ 1.5 times the ULN, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 times ULN Exclusion Criteria: • Presence of active / uncontrolled central nervous system involvement • History of clinically significant cardiac disease; uncontrolled
hypertension • Left ventricular ejection fraction (LVEF) < 45 % • Allogeneic stem cell transplant within 100 days before first dose of study
drug • Known history of human immunodeficiency virus (HIV) infection • Chronic or active hepatitis B or C, requiring antiviral therapy • Evidence of history of bleeding disorder, dialysis, or coexisting cancer that is distinct in primary site or histology from the cancer evaluated in this study • Serious, uncontrolled infection • Unresolved chronic toxicity > grade 1 from prior therapy •
Use of strong CYP3A4 inhibitors or strong inducers within 7 days prior to the start of study treatment and for the duration of the study
Just as we can now effectively treat HIV - infected patients with a cocktail of antiretroviral
drugs — and we treat people with
hypertension using diuretics, beta blockers and other
drugs — we expect to treat patients with complex neurological conditions with
drug combinations that target both the worst symptoms and the root causes of the diseases.
Edward Bullmore, UK Robert Dow, UK Garrett Fitzgerald, USA - Prostanoid biology and the role of peripheral molecular clocks in cardiovascular biology, metabolism and aging Alex Phipps, UK - Oncology, Clinical Pharmacology, Biologics and Immunotherapy Patrick du Souich, Canada - Cytochrome P450, membrane carriers, disease, inflammation, rational
use of
drugs, clinical pharmacology David J. Webb, UK -
hypertension, chronic kidney disease, endothelial function and dysfunction, arterial stiffness, health technology assessment, medicines regulation Don Birkett, Australia - Clinical pharmacology / pharmacokinetics and
drug utilisation
Drugs are often
used to lower aldosterone levels in individuals with
hypertension.
Various conditions and medications can lead to secondary
hypertension, including: Kidney problems; Adrenal gland tumors; Thyroid problems; Certain defects in blood vessels you're born with (congenital); Certain medications, such as birth control pills, cold remedies, decongestants, over-the-counter pain relievers and some prescription
drugs; Illegal
drugs, such as cocaine and amphetamines; Alcohol abuse or chronic alcohol
use; Obstructive sleep apnea.
Topamax This
drug is frequently prescribed for epilepsy and migraines, as well as the off - label
uses, including treatment of bipolar disorder, obesity, bulimia, neuropathic pain, obsessive - compulsive disorder, idiopathic intracranial
hypertension, and alcoholism.