Sentences with word «hypertriglyceridemia»

UCLA researchers have discovered a subset of people with hypertriglyceridemia whose bodies produce autoantibodies — immune - response molecules that attack their own proteins — causing high levels of triglycerides in the blood.

Management of hypertriglyceridemia includes counseling for lifestyle changes, such as weight control, dietary changes, and exercise.

Hyperinsulinemia in fructose - induced hypertriglyceridemia in the rat.

The effect of Vascepa on the risk for pancreatitis and cardiovascular mortality and morbidity in patients with severe hypertriglyceridemia has not been determined.

In their new research, Young, Beigneux, Fong and Katsuyuki Nakajima, a professor at Gunma University in Japan, found a group of people with hypertriglyceridemia whose GPIHBP1 can't transport lipoprotein lipase into capillaries.

LPL is a pivotal player in TG metabolism, as mutations in LPL or in its cofactors (ApoC - II, glycosylphosphatidylinositol - anchored high - density lipoprotein — binding protein 1, lipase maturation factor 1) account for the majority of monogenic hypertriglyceridemia cases (25).

High triglyceride levels: Triglycerides ≥ 150 mg / dL (or receiving drug therapy for hypertriglyceridemia)

Hypertriglyceridemia results from the accumulation of TG - rich lipoproteins (TRLs) in the circulation.

People with hypertriglyceridemia often are told to change their diet and lose weight.

«New cause of high plasma triglycerides discovered: Autoantibodies, which attack people's own proteins, cause some cases of a condition known as hypertriglyceridemia.»

This newly discovered syndrome, dubbed the «GPIHBP1 autoantibody syndrome,» represents an important advance in understanding hypertriglyceridemia, said Dr. Stephen Young, UCLA cardiologist and molecular biologist, who led the study along with his colleagues Anne Beigneux and Loren Fong.

In conclusion, our genetic studies establish the fact that ApoC - III ASO reduces hypertriglyceridemia in mice by reducing plasma ApoC - III levels, which in turn enhances clearance of TRLs through LDLR family members.

The addition of sacha inchi oil slowed down glucose production in 16 (38.1 %) participants that showed a higher concentration of triglycerides before meals (fasting hypertriglyceridemia), whereas an improved expression of sirtuin - 1 (SIRT1), a gene responsible for regulating energy within the cells and coordinating cellular functions, was registered four hours after ingesting the meal enriched with sacha inchi oil, and linked to lowered levels of blood sugar measured at the same time.

Induction of insulin resistance is thought to be mediated by elevated TNF - alpha production by adipose cells and by hypertriglyceridemia.

The upside is you have less hypertriglyceridemia and fatty liver.

Patient with gemfibrozil - controlled hypertriglyceridemia that developed acute pancreatitis after starting ketogenic diet

, Tomato juice intake increases resting energy expenditure and improves hypertriglyceridemia in middle - aged women: an open - label, single - arm study, 2015

NIDDM patients with hypertriglyceridemia who do not need to lose weight are candidates for a high - MUFA diet.

After an initial level of care is provided, your veterinarian will address problems such as blood sugar (hyperglycemia) and too much fat (triglycerides) in the blood (called hypertriglyceridemia).

«Decoding mechanisms opens the door to precise, individual interventions for the prevention of residual risk associated with the various causes of severe hypertriglyceridemia,» Dr. Gaudet said.

Last December, the same research team demonstrated blocking the expression of the gene that encodes apoC - III led to major relief of triglyceridemia in patients suffering a rare and extreme form of hypertriglyceridemia, which in turn opened the door for the identification of unexpected mechanisms that govern blood fat.

Sucrose is made up of glucose and fructose and it has been shown that diets very high in sucrose or fructose (~ 60 - 70 % by energy) can induce hypertriglyceridemia, insulin resistance and fatty liver.

Approach to the patient with hypertriglyceridemia.

Vascepa (icosapent ethyl) is indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥ 500 mg / dL) hypertriglyceridemia.

Vascepa has been approved for use by the United States Food and Drug Administration (FDA) as an adjunct to diet to reduce triglyceride levels in adult patients with severe (≥ 500 mg / dL) hypertriglyceridemia.

If you regularly eat more calories than you burn, particularly «easy» calories like carbohydrates and fats, you may have high triglycerides (hypertriglyceridemia).

Although rare forms of genetic triglyceride accumulation exist, for which there are few effective treatments, hypertriglyceridemia is the one most often associated with frequent health issues, such as obesity or diabetes.

«The results of these studies enable the acceleration of research targeting better understanding and control of the risk trajectory associated with various forms of severe hypertriglyceridemia.»

By blocking the expression of a certain gene in patients, University of Montreal researchers have contributed to the demonstration of great decreases in the concentration of triglycerides in their blood, even in various severe forms of hypertriglyceridemia and regardless of the base values or the treatment the patient usually receives.

Hypertriglyceridemia, a condition in which fasting triglyceride levels are greater than 150 mg / dL, is estimated to affect at least tens of millions of American adults.

Added Young: «GPIHBP1 autoantibodies need to be considered in any new case of severe hypertriglyceridemia.»

The UCLA team went on to show that some people with hypertriglyceridemia have mutations in GPIHBP1 that keep it from binding to LPL, while others have mutations in LPL that keep it from binding to GPIHBP1.

Hypertriglyceridemia, which can increase risk of both cardiovascular disease and pancreatitis, is often caused by or exacerbated by uncontrolled diabetes or obesity.

The autoantibodies against GPIHBP1 crossed the placenta and entered the baby's circulation; consequently, the newborn infant had severe hypertriglyceridemia.

However, despite decades of research and a growing understanding of triglyceride metabolism, most cases of hypertriglyceridemia are poorly understood.

As we have learned over the past few decades, an excess intake of refined carbohydrates is associated with increased weight gain, hypertriglyceridemia (hyper - TG), and insulin resistance (IR) in humans and animal models (5, 1).

Transgenic overexpression of APOC3 in mice also led to hypertriglyceridemia that was likely due to defective lipolysis (20), but it should be noted that an excess of any apolipoprotein has a similar effect (26 — 29), probably by shielding the core TG and preventing LPL access.

Hypertriglyceridemia is an independent risk factor for cardiovascular disease, and plasma triglycerides (TGs) correlate strongly with plasma apolipoprotein C - III (ApoC - III) levels.

But the importance of ApoC - III in TRL metabolism did not became fully apparent until it was shown that transgenic expression of APOC3 in mice resulted in hypertriglyceridemia (6), whereas a null mutation in the murine gene decreased plasma TG levels (7).

Our results support a model in which ApoC - III on TRLs contributes to hypertriglyceridemia, primarily by preventing TRL hepatic clearance via both LDLR and LRP1.

These ratios of ApoC - III to ApoC - II exceed the normal physiological range of these apolipoproteins present on human VLDL particles, even in patients with hypertriglyceridemia (0.7 to 2)(30).

In the new study, the researchers provided data suggesting that nearly five decades ago, the Sugar Research Foundation withheld evidence from the public that the microbiome might be an important contributing factor to sucrose - induced hypertriglyceridemia — or high levels of triglyceride fat — and that sucrose consumption, compared to starch, might be associated with bladder cancer.

Use cautiously with high VLDL cholesterol, hypertriglyceridemia, or with a history of low blood pressure, coagulation disorders, potential for mania, or epilepsy.